Amazing weight loss and sleep apnea treatment with NNC0487-0111

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 3, randomized, double-blind, placebo-controlled trial evaluating the safety and efficacy of NNC0487-0111 in adults with excess weight and obstructive sleep apnea not treated with positive airway pressure. Participants receive either NNC0487-0111 or a matched placebo by subcutaneous injection once a week for a specified period. The study compares weight loss and sleep apnea outcomes between groups, while monitoring safety and tolerability. Key eligibility includes adults with BMI indicating overweight/obesity and an AHI of 15 or higher, with several exclusions such as diabetes and recent ENT surgery. Conducted at multiple sites, the trial aims to determine if this medicine can provide meaningful benefits beyond current options.

Why it matters

Who can join: the full rules

Key Inclusion Criteria:

* Male or female (sex at birth)
* Age 18 years or above at the time of signing informed consent
* Previously diagnosed moderate-to-severe OSA with an AHI ≥ 15, as diagnosed with polysomnography (PSG), home sleep apnoea test (HSAT), or other method that meets local guidelines prior to screening

Key Exclusion Criteria:

* Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol/mol) as measured by the central laboratory at screening
* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records
* Any planned or previous surgery within 90 days prior to screening for sleep apnoea, including septoplasty, turbinoplasty, or other ear, nose, and throat surgeries, including tonsillectomy and adenoidectomy
* Significant craniofacial abnormalities that may affect breathing at baseline, for example Treacher Collins syndrome and Pierre Robin Sequence
* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonist (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening

Where it's running

• Artemis Insitute for Clin Res
  San Diego, California, United States Recruiting
• PharmaDev Clinical Research Institute LLC
  Miami, Florida, United States Recruiting
• Renstar Medical Research
  Ocala, Florida, United States Recruiting
• Conquest Research
  Atlanta, Georgia, United States Recruiting
• Physicians Research Associates
  Lawrenceville, Georgia, United States Recruiting
• University Of Chicago
  Chicago, Illinois, United States Recruiting

+30 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Novo Nordisk
• Email: clinicaltrials@novonordisk.com
• Phone: (+1) 866-867-7178

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.