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Clinical trial Recruiting at 2 sites Interventional Ages 18 to 85

Effects of weight loss on heart function in obese patients with heart failure

Official title: The Effects of Obesity and Weight Loss in Heart Failure: Imaging the Obesity Paradox Using Magnetic Resonance Imaging and Spectroscopy - Heart Failure With Reduced Ejection Fraction Substudy

Run by University of Oxford · NCT05942287 · Data updated 2026-11-12

This study tests if losing weight can help people with heart failure feel better and improve their heart function.

More Obesity trials

Quick facts

Study typeInterventional
Ages18 Years to 85 Years
SexAll
Enrollment110 (estimated)
SponsorUniversity of Oxford
Academic / other
Locations2 sites (Jersey, Jersey and 1 other locations)
StatusRecruiting
StartedMay 24, 2023
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedFebruary 25, 2025
Trial IDNCT05942287 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals with heart failure characterized by a left ventricular ejection fraction of 20-45% and a body mass index greater than 27.5 kg/m².

Probably not a fit

Patients with contraindications to MRI, those in NYHA class IV, or with significant other cardiac conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how weight loss impacts individuals with heart failure and reduced ejection fraction who are overweight or obese. Participants will be randomly assigned to either a diet intervention group or a control group receiving standard care. The study will involve two visits over a period of 3-6 months, during which various assessments will be conducted, including heart imaging and quality of life questionnaires. The primary focus is to determine if weight loss can improve heart function and overall well-being in this patient population.

Why it matters

Potential benefit: If successful, this study could lead to improved heart function and quality of life for patients with heart failure and obesity.

How similar studies have gone: Other studies have shown promising results in weight loss interventions for heart failure patients, suggesting potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Heart failure determined by left ventricular ejection fraction 20-45%
* Body mass index \> 27.5kg/m\^2

Exclusion Criteria:

* Contraindications to magnetic resonance imaging
* NYHA class IV
* Pregnancy, planned pregnancy or lactating
* Significant valvular, ischemic, infiltrative or other potentially confounding cardiac disease
* Any other conditions which may potentially compromise the safety or scientific validity of the study

Where it's running

  • Jersey General Hospital
    Jersey, Jersey, Jersey     Recruiting
  • Jenny Rayner
    Oxford, United Kingdom     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Heart Failure 1020Heart Failure With Reduced Ejection Fraction 44Obesity 1426Overweight 159University of Oxford 90
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.