Effects of weight loss on heart function in obese patients with heart failure
The Effects of Obesity and Weight Loss in Heart Failure: Imaging the Obesity Paradox Using Magnetic Resonance Imaging and Spectroscopy - Heart Failure With Reduced Ejection Fraction Substudy
This study tests if losing weight can help people with heart failure feel better and improve their heart function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | University of Oxford Academic / other |
| Locations | 2 sites (Jersey, Jersey and 1 other locations) |
| Trial ID | NCT05942287 on ClinicalTrials.gov |
What this trial studies
This study investigates how weight loss impacts individuals with heart failure and reduced ejection fraction who are overweight or obese. Participants will be randomly assigned to either a diet intervention group or a control group receiving standard care. The study will involve two visits over a period of 3-6 months, during which various assessments will be conducted, including heart imaging and quality of life questionnaires. The primary focus is to determine if weight loss can improve heart function and overall well-being in this patient population.
Who should consider this trial
Good fit: Ideal candidates are individuals with heart failure characterized by a left ventricular ejection fraction of 20-45% and a body mass index greater than 27.5 kg/m².
Not a fit: Patients with contraindications to MRI, those in NYHA class IV, or with significant other cardiac conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved heart function and quality of life for patients with heart failure and obesity.
How similar studies have performed: Other studies have shown promising results in weight loss interventions for heart failure patients, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Heart failure determined by left ventricular ejection fraction 20-45% * Body mass index \> 27.5kg/m\^2 Exclusion Criteria: * Contraindications to magnetic resonance imaging * NYHA class IV * Pregnancy, planned pregnancy or lactating * Significant valvular, ischemic, infiltrative or other potentially confounding cardiac disease * Any other conditions which may potentially compromise the safety or scientific validity of the study
Where this trial is running
Jersey, Jersey and 1 other locations
- Jersey General Hospital — Jersey, Jersey, Jersey (Recruiting)
- Jenny Rayner — Oxford, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Oliver J Rider, DPhil — University of Oxford
- Study coordinator: Jenny Rayner, DPhil
- Email: jenny.rayner@cardiov.ox.ac.uk
- Phone: +441865221172
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.