Condition

Obese clinical trials and research

• 12Clinical trials
• 72NIH research projects
• 6Countries

Newest Obese clinical trials

All recruiting trials (12)

• Mechanical ventilation strategy to protect the lungs in obese adults during laparoscopic or robotic surgery

  This trial tests whether a specific intraoperative PEEP approach that uses transpulmonary pressure to limit lung power can improve breathing after surgery for adults with BMI 35 or higher undergoing laparoscopic or robotic procedures.

  Recruiting The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT07774065

• Combined resistance training and high-protein diet to help frailty in sarcopenic obesity women

  This trial tests whether adding supervised resistance exercise to a high-protein diet helps frailty in obese, sarcopenic women.

  Recruiting Cairo University · El-Sheikh Zayed City · NCT07627919

• SA030 Injection in Adults with Overweight or Obesity (Phase 1)

  This first-in-human study tests a single dose of SA030 to see if it is safe and well tolerated in adults who are overweight or obese.

  Recruiting at 2 sites Phase 1 Suzhou Siran Biotechnology Co.,Ltd. · Brisbane, Queensland and 1 other locations · NCT07479862

• Weekly injections of GIP (NNC0480-0389) plus amylin (cagrilintide) to see stomach side effects in adults with overweight or obesity

  This trial tests whether adding a GIP injection (NNC0480-0389) to weekly cagrilintide changes stomach-related side effects in adults with overweight or obesity.

  Recruiting Phase 1 Novo Nordisk A/S · Harrow, Middlesex · NCT07411560

• MB-1 vs placebo for weight and metabolic health in adults who are overweight or obese

  A study will test MB-1 to see if it helps adults who are overweight or obese lose weight and improve metabolic health compared to a placebo.

  Recruiting Arrae · London, Ontario · NCT07363148

• Testing HM17321 injections to find safe dose ranges in healthy and obese adults

  This study will try single and multiple doses of HM17321 injections in healthy adults and adults with obesity to see if they are safe and how the body processes the drug.

  Recruiting Phase 1 Hanmi Pharmaceutical Company Limited · Cincinnati, Ohio · NCT07219589

• Using a new endoscopy technique for bariatric patients

  This study is testing a new, less invasive endoscopy method for bariatric patients to see if it can improve safety and reduce costs when checking for stomach and digestive issues.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06200961

• Understanding how obesity affects exercise response

  This study looks at how obesity affects exercise and muscle function in adults aged 20 to 45 to see if chronic inflammation plays a role.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05857150

• Using Semaglutide to Restore Ovulation in Young Women with PCOS

  This study is testing if a medication called semaglutide can help young women with PCOS and obesity start ovulating again.

  Recruiting Phase 3 University of Colorado, Denver · Aurora, Colorado · NCT05819853

• Optimizing diet and physical activity for taxi drivers

  This study is trying to help taxi drivers who are overweight or obese make healthier choices about their diet and exercise through personalized support and tools.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT05770570

• Investigating inflammation and insulin resistance in obese individuals

  This study is trying to see if certain molecules can help reduce inflammation and insulin resistance in people who are obese and have had gastric bypass surgery.

  Recruiting Göteborg University · Gothenburg, Västra Götaland County · NCT04255264

• Tailored lifestyle intervention for obese children

  This study is testing a personalized program to help obese kids aged 6 to 17 become more active and improve their health using wearable sensors to track their movements.

  Recruiting St. Justine's Hospital · Montreal, Quebec · NCT01736748

NIH-funded research (newest 40 of 72)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Adipome biomarkers in obese TNBC mice for targeted therapy

  A study in mice explores how fat-derived particles called adipomes influence an aggressive breast cancer type, with the goal of guiding personalized therapies.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11457952

• Metabolic-driven stem cells and inflammatory niches in early-onset colorectal cancer

  Researchers are studying how metabolic changes from obesity and diet may fuel early-onset colorectal cancer by linking stem cell biology and inflammation in patients.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11445548

• Improving awareness of heart disease risks in women through a career enhancement program

  A national program helps trained researchers learn how sex and age factors affect blood pressure and heart disease in women, with a focus on communities in Georgia, Mississippi, and South Carolina.

  NIH research Augusta University · Augusta, United States · NIH-11408765

• ROAR: Leading Awareness on Women’s Hypertension in Rural, Obese, At-Risk Populations

  A nationwide project helps raise awareness about high blood pressure in adult women, especially in rural communities with higher risk, to reduce heart disease risk.

  NIH research Augusta University · Augusta, United States · NIH-11408758

• ROAR: Raising Awareness of Hypertension in Rural, Obese, At-Risk Women

  A patient-friendly program aims to raise awareness about high blood pressure and heart disease in adult women, especially in rural communities and among Black populations.

  NIH research Augusta University · Augusta, United States · NIH-11408745

• Lipid anti-Inflammatory Mediators in Asthma for Obese Individuals

  A study testing a novel lipid-based drug, CXA-10, to help adults with obesity-related asthma breathe better and control their symptoms.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11394482

• AI approach to strengthening therapy for overweight African American teens and families

  A study uses artificial intelligence to help therapists build stronger, more trusting relationships with African American teenagers who are managing obesity and their caregivers.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11394032

• Diet, gut microbes, and metabolic health in families to prevent early colorectal cancer

  A family-based dietary plan targets gut microbes and metabolic inflammation in adults and children at higher risk for colorectal cancer.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11373519

• Uncovering hidden factors that shape influenza vaccine responses in older adults who are healthy or obese

  Scientists are studying why flu vaccines work differently in older adults who are healthy or have obesity, using high-tech blood and cell analyses to look for clues.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11367479

• Engineered Colon Cancer Tissue in Obese Environments

  Aims to study how obesity-related changes in the tumor environment influence colorectal cancer using patient-derived, lab-made colon cancer models.

  NIH research Auburn University at Auburn · Auburn, UNITED STATES · NIH-11355575

• Mitochondria changes in babies born to obese mothers

  A study in adults and animal models looks at how obesity during pregnancy affects mitochondria in offspring and whether antioxidants during pregnancy can prevent future obesity.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11345205

• Online lifestyle program to reduce obese frailty in men with prostate cancer on hormone therapy

  A digital program combines diet and online exercise to help men with prostate cancer who are on hormone therapy lose excess weight and improve frailty.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11323443

• Weight loss and exercise to improve mobility and well-being after stroke in obese veterans

  A study tests whether adding weight loss with or without supervised exercise can help improve physical function and quality of life for obese veterans recovering from stroke.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11317084

• How a mother's triglyceride levels influence newborn body and liver fat in pregnancies with obesity

  This project looks at whether higher maternal blood triglycerides during pregnancy are linked to more body and liver fat in newborns of people with overweight or obesity.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11312645

• How a mother's obesity can change her child's immune system and metabolism

  Researchers are working to understand why children born to mothers who were obese before pregnancy often develop lasting immune and metabolic problems.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11302712

• Predictors of inhaled corticosteroid response in asthma across BMI and race

  A patient-focused study aims to find metabolite and genetic signals that predict how well people with asthma, including those who are overweight or from high-risk groups, respond to inhaled steroids.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11281064

• How changing estrogen and fat inflammation raise breast cancer risk and spread in obese women

  Researchers are exploring how the postmenopausal estrogen estrone and inflammation in breast fat may drive higher risk and spread of ER-positive breast cancer in obese women.

  NIH research Georgetown University · Washington, United States · NIH-11238022

• How parental obesity affects kidney disease in their children

  This NIH grant investigates why children of obese parents may be more at risk for kidney problems and inflammation, and how certain kidney cells contribute to this risk.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11227049

• How weight change affects knee osteoarthritis in people who are overweight or obese

  This project looks at how losing or gaining weight affects knee arthritis in adults who are overweight or obese.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11225134

• How obesity and diet in parents and children may raise early-onset colorectal cancer risk

  Testing whether an anti-inflammatory diet that changes gut microbes can lower inflammation and future colorectal cancer risk in overweight parents and their children.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11220725

• Metformin for asthma in overweight and obese adults

  This project tests whether metformin can help improve asthma control in overweight and obese adults.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11195075

• ROAR: helping rural, obese, at‑risk women understand high blood pressure

  This project will build community education and outreach to help rural, obese, and Black women recognize and manage high blood pressure.

  NIH research Augusta University · Augusta, United States · NIH-11180412

• Metformin to reduce lung cancer risk in overweight or obese former smokers

  This project will see whether the common diabetes pill metformin can help prevent lung cancer in overweight or obese people who used to smoke.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11141784

• AI to strengthen therapist-family connections for obese African American teens

  This project uses artificial intelligence to help community health workers connect more empathetically with African American adolescents with obesity and their caregivers during family-based therapy.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11138434

• Understanding Colon Cancer Growth in Obese Patients

  This project explores how obesity affects the growth and behavior of colon cancer cells to find new ways to help patients.

  NIH research Auburn University at Auburn · Auburn, UNITED STATES · NIH-11131100

• Better Blood Sugar Goals for Pregnant Women with Gestational Diabetes Who Are Overweight or Obese

  This project looks at whether stricter blood sugar goals can help pregnant women who have gestational diabetes and are also overweight or obese have healthier pregnancies and babies.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11124050

• Helping overweight and obese Veterans become more active using games and social support

  This project is testing if a fun, game-like program with social encouragement can help overweight and obese Veterans become more physically active.

  NIH research Philadelphia VA Medical Center · Philadelphia, United States · NIH-11123243

• How obesity in mothers affects the health of their children

  This study looks at how being overweight during pregnancy can affect the health of children later on, especially regarding heart and metabolic issues, using mice to understand the effects of a high-fat diet on both moms and their babies.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11116535

• Online program to help prostate cancer survivors manage obesity and frailty

  This study is testing an online program that helps prostate cancer survivors who are dealing with weight gain and weakness from their treatment, by offering them healthy eating tips and guided exercise to boost their health and well-being.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11112503

• Understanding Flu Vaccine Protection in Older Adults

  This research wants to understand why some older adults get strong protection from the flu vaccine while others get weaker protection, especially if they are also obese.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11109633

• How resistance training affects fat metabolism in obese postmenopausal women

  This study is looking at how different types of exercise, like lifting weights versus doing cardio, affect how your body breaks down fat if you're an obese woman who has gone through menopause, to help find better ways to manage weight.

  NIH research Florida State University · Tallahassee, United States · NIH-11099983

• Investigating the gut bacteria in lean and obese youth with type 1 diabetes and how metformin affects them

  This study is looking at how the bacteria in the gut might be different in kids with type 1 diabetes who are either obese or lean, and it also wants to see if the diabetes medicine metformin can help improve their gut health and insulin use, all to find ways to help these young people feel better.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11099668

• Effects of daily calorie reduction on kidney health in overweight adults with ADPKD

  This study is looking at how eating fewer calories each day might help improve kidney health for adults with autosomal dominant polycystic kidney disease (ADPKD) who are overweight or obese, and it aims to see if this can slow down kidney problems while also helping with weight management.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11098556

• Weight Loss, Bone Health, and Fracture Risk in Type 2 Diabetes

  This project explores why people with type 2 diabetes who lose weight through an intensive program might have a higher chance of bone fractures.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11093537

• How triglycerides in pregnant women affect fat in newborns

  This study is looking at how the fat levels in newborns might be influenced by the triglyceride levels in their mothers during pregnancy, especially for babies born to moms who are obese, to help understand potential health risks for the little ones later on.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11083158

• How maternal obesity affects asthma risk in children

  This study looks at how being overweight during pregnancy might affect a child's chances of developing asthma, using mice to understand how changes in the lungs and nerves happen, with the hope of finding ways to help kids who might be at risk.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11078357

• Improving movement and mental health in obese veterans after a stroke through weight loss and exercise

  This study is looking to help veterans who are overweight and have had a stroke by trying out a 15-week program that mixes weight loss and exercise to see which approach works best for their recovery.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11059600

• How obesity in pregnancy affects the metabolism of offspring

  This study is looking at how being overweight during pregnancy might affect the health of babies by changing how their cells work, and it aims to find out if certain treatments can help prevent weight problems in their future.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11057293

• Investigating how innate lymphocytes affect asthma in obese individuals

  This study is looking at how being overweight might make asthma worse, especially in women, by exploring the role of certain immune cells in the body, using a special mouse model that reflects the health issues seen in people; the goal is to find better ways to treat asthma for those who are obese.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11005388

• Investigating the role of specific immune cells in asthma related to obesity

  This study is looking at how being overweight can make asthma worse in women by comparing the immune responses in heavier and lighter mice with asthma, hoping to find new ways to help treat asthma flare-ups related to obesity.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11002342

Related topics

Quick answers

How many Obese clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (6 trials), Canada (2 trials), Sweden (1 trial), United Kingdom (1 trial), Egypt (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →