Better Blood Sugar Goals for Pregnant Women with Gestational Diabetes Who Are Overweight or Obese

Intensive Glycemic Targets in Overweight and Obese Women with Gestational Diabetes Mellitus: A Multicenter Randomized Trial

NIH-funded research Indiana University Indianapolis · NIH-11124050

This project looks at whether stricter blood sugar goals can help pregnant women who have gestational diabetes and are also overweight or obese have healthier pregnancies and babies.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionIndiana University Indianapolis NIH-funded
Lab location1 site (Indianapolis, United States)
Project IDNIH-11124050 on NIH RePORTER

What this research studies

Many pregnant women today are both overweight or obese and develop gestational diabetes, which can lead to complications for both mother and baby. Current recommendations for managing blood sugar during pregnancy might not be strict enough for these women. This project compares two different approaches to blood sugar control: a standard approach and a more intensive approach with lower target levels. We want to see if aiming for these lower blood sugar levels can improve health outcomes for mothers and their newborns.

Who could benefit from this research

Good fit: Ideal candidates are pregnant women who have been diagnosed with gestational diabetes and are also overweight or obese.

Not a fit: Patients who do not have gestational diabetes or are not overweight or obese would likely not receive direct benefit from this specific approach.

Why it matters

Potential benefit: If successful, this work could lead to clearer guidelines for managing gestational diabetes in overweight and obese pregnant women, potentially reducing complications like fetal overgrowth and cesarean deliveries.

How similar studies have performed: Prior work by the researchers has shown that intensive glycemic targets can improve blood sugar control without increasing the risk of low blood sugar.

Where this research is happening

Indianapolis, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Diabetes Mellitus
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.