Eloralintide for weight loss in adults with overweight or obesity and type 2 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 3 interventional study gives participants either eloralintide or a matching placebo and follows them for roughly 75 weeks to measure body weight change and safety outcomes. Eligible participants must have type 2 diabetes, be on a stable diabetes treatment for at least 90 days, have a BMI of 27 kg/m2 or higher, and have stable weight in the prior 90 days. People who recently used GLP-1/GIP agents, amylin analogs, or insulin, or who had recent major cardiovascular events, are excluded, as are those with recent or planned surgical/device obesity interventions. The primary focus is on body weight reduction with concurrent monitoring of diabetes control and adverse events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have type 2 diabetes
* Are on stable treatment for type 2 diabetes for at least 90 days prior to screening
* Have a BMI ≥ 27 kg/m2
* Have a stable body weight (\<5% body weight change) for 90 days prior to screening

Exclusion Criteria:

* Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
* Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
* Have type 1 diabetes
* Have taken any of the following antihyperglycemic medications within 90 days before screening:

  * amylin analogs
  * glucagon-like peptide-1 (GLP-1) receptor agonists
  * glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or
  * insulin
* Have had within 90 days prior to screening:

  * heart attack
  * stroke
  * coronary artery revascularization
  * unstable angina, or
  * hospitalization due to congestive heart failure
* Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
* Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Where it's running

• Birmingham Clinical Research
  Birmingham, Alabama, United States Recruiting
• Cullman Clinical Trials
  Cullman, Alabama, United States Recruiting
• Tucson Clinical Research Institute
  Tucson, Arizona, United States Recruiting
• San Fernando Valley Health Institute
  Canoga Park, California, United States Recruiting
• AMCR Institute
  Escondido, California, United States Recruiting
• NorCal Medical Research, Inc
  Greenbrae, California, United States Recruiting

+93 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
• Email: LillyTrials@Lilly.com
• Phone: 317-615-4559

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.