Genotype-based versus standard dietary counseling to reduce weight and body fat.
Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction
NA · Metropolitan College · NCT07368777
This test sees if dietary advice based on your genes helps Greek adults with overweight lose more weight and reduce body fat compared with standard dietary advice.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 88 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Metropolitan College (other) |
| Locations | 1 site (Marousi) |
| Trial ID | NCT07368777 on ClinicalTrials.gov |
What this trial studies
Adults with BMI ≥25 who speak Greek will receive individualized dietary guidance either informed by their genotype or based on conventional dietary guidelines. Participants will attend counseling sessions at the Metropolitan College Dietetics Department and researchers will track changes in body weight and body composition over the intervention period. The trial compares weight loss and fat mass reduction between the genotype-guided arm and the standard counseling arm. Additional measures such as adherence and dietary changes may also be collected to contextualize outcomes.
Who should consider this trial
Good fit: Adults aged 18 or older with BMI ≥25 who read and speak Greek and are willing to participate in dietary counseling and study assessments are the ideal candidates.
Not a fit: People using prescription weight-loss medications, those recently in structured weight-loss programs, pregnant or lactating individuals, or people with medical conditions or medications that strongly affect body weight are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, genetic-guided dietary counseling could help people with overweight lose more weight and reduce body fat by tailoring recommendations to their biology.
How similar studies have performed: Nutrigenetic counseling studies to date have produced mixed results, with some trials reporting modest benefits and others showing no clear advantage over standard advice.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged ≥18 years * Body mass index (BMI) ≥25 kg/m² * Greek-speaking (able to read and understand Greek and provide informed consent) * Willing and able to participate in dietary counseling and study assessments for the duration of the study Exclusion Criteria: * Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications * Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions * Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders * Pregnancy or lactation * Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders
Where this trial is running
Marousi
- Dietetics Department, School of Health Sciences, Metropolitan College — Marousi, Greece (RECRUITING)
Study contacts
- Principal investigator: Angeliki Kapellou, PhD — Dietetics Department, School of Health Sciences, Metropolitan College
- Study coordinator: Angeliki Kapellou, PhD
- Email: akapellou@mitropolitiko.edu.gr
- Phone: +30 6938406218
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Overweight, Overweight and Obesity, Adiposity, genotype-based nutrition, dietary counseling, weight loss, nutrigenetics