Improving asthma control in overweight adults with late-onset asthma using L-citrulline
Official title: SANDIA: Supplementing L-citrulline to overweight late Asthma oNset phenotypes to increase airway L-arginine/ADMA ratio and Improve Asthma control
Funded at University of Colorado Denver · NIH-10692823 · Data updated 2026-11-12
This study is looking at how taking L-citrulline might help overweight adults who developed asthma later in life by improving their breathing and reducing asthma symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $700,666 |
| NIH project number | 5R01HL146542-05 |
| Project ID | NIH-10692823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are overweight adults who have developed asthma after childhood and experience poorly controlled symptoms.
✕Less likely to help
Patients who do not have late-onset asthma or are not overweight may not benefit from this research.
What this research studies
This research investigates the effects of supplementing L-citrulline in overweight adults who developed asthma later in life. The study focuses on understanding how this supplementation can improve the balance of L-arginine and asymmetric dimethylarginine (ADMA) in the body, which is crucial for better airway function. By addressing the unique inflammatory responses in this group, the research aims to enhance asthma control and overall respiratory health. Participants will be monitored for changes in their asthma symptoms and lung function as part of the study.
Why it matters
Potential benefit: If successful, this research could lead to improved asthma management and quality of life for overweight adults with late-onset asthma.
How similar studies have gone: Previous research has shown promising results in using similar approaches to improve asthma control in specific patient populations, indicating potential for success in this study.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Holguin, Fernando — University of Colorado Denver
- Study coordinator: Holguin, Fernando
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.