InRAD international registry for Alzheimer's disease and related dementias

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The InRAD Observational Study is a prospective, non-interventional, multinational registry that collects real-world clinical data from adults undergoing diagnostic work-up for or living with Alzheimer's disease. Participating centers record demographics, comorbidities, diagnostic and monitoring tests, medication exposures, cognitive and functional measures, and adverse events during routine care, typically with at least annual visits. Data are pseudonymized and pooled to allow comparison of disease trajectories, treatment safety, and outcomes across countries and regions over many years. Operational management and system support are provided by the InRAD Foundation while individual centers remain the data controllers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Be undergoing diagnostic work-up for Alzheimer's disease (AD), OR
* Have a confirmed diagnosis of AD (whether currently treated with an AD-specific treatment, or untreated),
* Be attending an InRAD Center,
* Have provided informed consent for long-term follow-up

Exclusion Criteria:

-Any patient or legal representative who is unable or unwilling to provide a signed informed consent form

The protocol does not specify a lower or upper age limit. Participants are expected to be predominantly adults, and can include younger adults with early-onset or genetically determined Alzheimer's disease (e.g. Down syndrome-associated Alzheimer's disease).

Where it's running

• Alfred Hospital
  Melbourne, Australia Recruiting
• Medical University of Graz
  Graz, Austria Recruiting
• Kardinal Schwarzenberg Klinikum
  Schwarzach, Austria Recruiting
• UZLeuven
  Leuven, Belgium Recruiting
• Irmandade da Santa Casa de São Paulo
  São Paulo, Brazil Recruiting
• Motol and Homolka University Hospital (UHM)
  Prague, Czechia Recruiting

Study contacts

• Study coordinator: Scientific Officer
• Email: office@inradnetwork.org

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• China HEAD: a large community study on healthy aging and dementia

  This study tests whether collecting health, imaging, and biospecimen data from adults in China can help predict who will develop Alzheimer’s disease and related dementias.

  Recruiting at 30 sites Fudan University · Beijing and 29 other locations · NCT07912710

• Aging Brain Health Initiative in Fujian

  This observational study will follow about 3,000 older adults in Fujian to see how Alzheimer's-related changes develop and to test new digital tests, biomarkers, and imaging tools for early diagnosis.

  Recruiting at 4 sites Fujian Medical University Union Hospital · Fushun, Fujian and 3 other locations · NCT07891429

• Digital tools to predict Alzheimer's biology from risk factors

  This study tests a digital, AI-based tool that analyzes modifiable and non-modifiable risk factors to see if it can predict biological changes linked to Alzheimer's disease in adults with MCI or SCD.

  Recruiting at 2 sites IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia, BS and 1 other locations · NCT07731191

• Community screening with blood biomarkers for Alzheimer's in older adults

  This project will test whether two blood biomarkers (pTau217/Aβ42 ratio and GFAP) can detect Alzheimer's disease or mild cognitive impairment in community-dwelling older adults.

  Recruiting at 4 sites Shanghai Fengxian District Central Hospital · Shanghai, Shanghai Municipality and 3 other locations · NCT07570719

• Online positive psychology program to support thinking and brain health in early memory changes

  This study will test whether an online positive psychology program can improve thinking, brain function, and wellbeing in older adults with early memory problems (Subjective Cognitive Decline or Mild Cognitive Impairment).

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki · NCT07289061

• Personalized digital training for cognitive fitness in people with mild cognitive impairment

  This study tests whether a personalized home-based digital program (RICORDO) helps people aged 50 and older with mild cognitive impairment or subjective cognitive decline manage their health and daily life better than a paper-and-video education program.

  Recruiting at 2 sites University of Modena and Reggio Emilia · Modena, Reggio Nell'Emilia (RE) and 1 other locations · NCT07286448

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.