RICORDO digital cognitive rehabilitation program for older adults
Official title: Transcultural and Multidimensional Validation of dIgital Rehabilitation Intervention of COgnitive Resources Domain-Oriented - Work Package 4
Run by Fondazione Don Carlo Gnocchi ETS · NCT07064226 · Data updated 2026-11-12
This project will test whether the RICORDO digital rehabilitation program can help people aged 65 and older with subjective memory complaints, mild cognitive impairment, or mild Alzheimer's dementia improve thinking skills and better manage their own health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 102 (estimated) |
| Sponsor | Fondazione Don Carlo Gnocchi ETS Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | October 6, 2025 |
| Main results expected | August 31, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | February 13, 2026 |
| Trial ID | NCT07064226 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people aged 65 or older with MoCA scores above 17.79, CDR ≤ 1, at least three years of education, a willing caregiver/study partner, and stable pharmacologic treatment for the past three months if applicable.
✕Probably not a fit
Patients with moderate-to-severe dementia, marked auditory/visual/communication impairments, significant motor problems, or those currently enrolled in another rehabilitation program are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional comparison tests RICORDO, an adaptive digital telerehabilitation system, against standard paper-and-pencil cognitive rehabilitation (treatment as usual). Participants aged 65+ with subjective memory complaints, mild cognitive impairment, or mild dementia receive a tailored multidomain rehabilitation pathway delivered by RICORDO or by usual care, supported by a caregiver as needed. Neuropsychological evaluations are performed immediately before, immediately after, and six months after the program to measure changes in global cognition and patient activation. The protocol requires stable medications and excludes people with major sensory, motor, or communication barriers or those already engaged in rehabilitation.
Why it matters
Potential benefit: If successful, RICORDO could improve overall cognitive function and patient engagement while providing a scalable, adaptable telerehabilitation option.
How similar studies have gone: Earlier telerehabilitation and digital cognitive-training studies in MCI and early dementia have shown modest benefits, but fully adaptive systems like RICORDO are relatively novel and less well-established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Montreal Cognitive Assessment (MoCA) score \> 17.79; 2. Clinical Dementia Rating (CDR) Scale score ≤ 1; 3. Education level \> 3 years; 4. Age ≥ 65 years; 5. Informed consent to participate, confirmed by signing the consent form; 6. Availability of a caregiver/study partner able to support the participant; 7. Stable pharmacological treatment (past 3 months) with acetylcholinesterase inhibitors, if applicable. Exclusion criteria: 1. Presence of dysmetria or marked auditory/visual or communication disorders preventing the participation to the trial; 2. Presence of ongoing rehabilitation program at the time of enrollment or in the 3 months prior to enrollment;
Where it's running
-
IRCCS Fondazione Don Carlo Gnocchi ONLUS; Center of Advance Diagnostic and Therapy ( CADiTeR)
Milan, Italy Recruiting
Study contacts
- Principal investigator: Valeria Blasi, Medical Doctor — IRCCS Fondazione Don Carlo Gnocchi ONLUS
- Study coordinator: Valeria Blasi, MD
- Email: vblasi@dongnocchi.it
- Phone: +390240308952
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.