Exploring the effects of sleep and exercise on Alzheimer's risk
Combating Alzheimer's Through Sleep and Exercise (CASE)
This study is testing how good sleep and regular exercise might lower the risk of developing Alzheimer's disease over time.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 45 Years to 80 Years |
| Sex | All |
| Sponsor | University of Miami Academic / other |
| Locations | 1 site (Miami, Florida) |
| Trial ID | NCT04855630 on ClinicalTrials.gov |
What this trial studies
This research investigates how sleep quality and physical exercise influence the risk of developing dementia over time. Participants will use a DREEM 2 Headband to monitor sleep patterns and engage in a structured exercise routine. The study aims to gather data on cognitive function and biomarkers through various assessments, including the Everlywell biomarker procedure. By analyzing these factors, the study seeks to identify potential preventative measures against Alzheimer's disease.
Who should consider this trial
Good fit: Ideal candidates include individuals who can perform mild exercise and have self-reported cognitive impairment.
Not a fit: Patients who are unable to perform mild exercise or use the required technology will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into lifestyle interventions that may reduce the risk of Alzheimer's disease.
How similar studies have performed: Other studies have shown promising results in using lifestyle interventions like exercise and sleep improvement to mitigate dementia risk, suggesting this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Able to perform mild exercise 2. Able to wear DREEM 2 Headband 3. Able to wear a Fitbit wrist watch 4. Able to perform the Everlywell biomarker procedure 5. Able to Understand and Speak English 6. Able to operate a digital device like mobile phone, iPad, or computer 7. Self-reported history of problems with cognitive impairment: memory, concentration, and processing information 8. Only participants cognitively able and willing to provide consent will be included. Exclusion Criteria: 1. Prohibited from or unable to perform mild exercise 2. Unable to wear wrist watch or headband devices, or unable to supply pinprick blood sample for any reason 3. Unable to speak or understand English 4. Unable to use mobile device/smartphone technology 5. Unable or unwilling to consent for any reason.
Where this trial is running
Miami, Florida
- University of Miami Hospitals — Miami, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Azizi A Seixas, PhD — University of Miami
- Study coordinator: Azizi A Seixas, PhD
- Email: Azizi.seixas@med.miami.edu
- Phone: 3052431301
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.