Hippocampal Temporal Interference Stimulation for Memory and Posture in Older Adults with Mild Cognitive Impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the immediate effects of a 40 Hz hippocampal temporal interference stimulation on memory performance and dual-task postural control in older adults with MCI. Participants will undergo three laboratory visits over about three weeks, receiving both active and sham stimulation in random order. The trial uses a randomized, sham-controlled design to assess short-term changes in cognitive and motor function. Eligibility includes age 65 or older with subjective memory concerns and objective cognitive impairment but no dementia, as determined by MoCA-BJ and CDR scores. The lead institution is Shanghai University of Sport, with participants recruited at that site.

Why it matters

Who can join: the full rules

1. Aged 65 years or older;
2. Presence of subjective memory complaints;
3. Objective cognitive impairment: screened using the Montreal Cognitive Assessment-Bejingversion (MoCA-BJ). The MoCA-BJ total score is 30 points. For individuals with \<12 years ofeducation, 1 point is added to the raw total score (corrected total score capped at 30 points); acorrected total score \<26 points indicates risk of cognitive impairment;
4. Clinical Dementia Rating (CDR) score of 0.5;
5. Does not meet diagnostic criteria for dementia: Mini-Mental State Examination (MMSE) scores\>18 for illiterate individuals, 221 for those with primary school education, and \>25 for those withjunior high school education or above;6. Retains independent activities of daily living (ADL) and is capable of cooperating with allassessments and interventions.

Where it's running

• Shanghai University of Sport
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Jiaojiao Lü, PhD
• Email: ljj27@163.com
• Phone: +86 18516565889

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.