Clinical trial Recruiting at 1 site Interventional Ages 50 to 100

Mindfulness meditation for improving cognition in older adults

Official title: Mechanisms of Mindfulness for Cognition in Early-Stage Alzheimer's Disease

Run by VA Boston Healthcare System · NCT06792877 · Data updated 2026-11-12

This study is testing whether mindfulness meditation can help older adults, including those with mild cognitive impairment, improve their thinking, memory, and overall quality of life.

Quick facts

Study typeInterventional
Ages50 Years to 100 Years
SexAll
Enrollment100 (estimated)
SponsorVA Boston Healthcare System
Federal
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedJanuary 23, 2025
Main results expectedJanuary 1, 2027
Study endsMarch 31, 2027
Registry record updatedJanuary 27, 2025
Trial IDNCT06792877 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include older adults with mild cognitive impairment or healthy elderly individuals who meet specific cognitive performance criteria.

Probably not a fit

Patients with moderate dementia, severe mood disorders, or other significant medical conditions affecting cognition may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to investigate the effects of mindfulness meditation on cognitive outcomes in older adults, including those with mild cognitive impairment and healthy elderly individuals. Participants will be randomly assigned to either a mindfulness intervention group or a waitlist control group, allowing researchers to compare cognitive performance, brain function, and quality of life between the two groups. The study seeks to determine how mindfulness practices can influence thinking, memory, and daily functioning in this population.

Why it matters

Potential benefit: If successful, this intervention could enhance cognitive function and quality of life for older adults, particularly those experiencing mild cognitive impairment.

How similar studies have gone: Previous studies have shown promising results for mindfulness interventions in improving cognitive function, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Healthy older adults will show cognitive performance within 1.0 SD for age \& education adjusted norms on a neuropsychological test battery
* Mild cognitive impairment (MCI) participants will show performance on delayed recall or one more or more other cognitive domains worse than 1.5 SD for age \& education adjusted norms, an MMSE score between 25-30, and a MoCA score between 20-30.

Exclusion Criteria:

* Participants without a computer, smart phone and internet access will be excluded
* If they cannot understand the informed consent form or have moderate dementia.
* Mood disorders (e.g., PTSD, depression, anxiety) or alcohol and drug use that either interferes with day-to-day life or required hospitalization within the past 5 years
* Cerebrovascular disease
* Any medical condition whose severity could significantly impair cognition (e.g., stroke, frontotermporal dementia, Parkinson's disease) are exclusionary

Where it's running

  • VA Boston Healthcare System - Jamaica Plain Campus
    Boston, Massachusetts, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.