Investigating brain mechanisms for cognitive assessment and rehabilitation in cognitive decline
Official title: Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline
Run by National Research Center for Rehabilitation Technical Aids · NCT05014893 · Data updated 2026-11-12
This study is testing different ways to improve thinking skills in people with mild cognitive decline by looking at brain activity and trying out activities like training, exercise, and games.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | National Research Center for Rehabilitation Technical Aids Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | August 6, 2021 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | May 22, 2025 |
| Trial ID | NCT05014893 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults with subjective cognitive decline, mild cognitive impairment, or those with normal cognitive function who can walk at least a block.
✕Probably not a fit
Patients with a clinical diagnosis of dementia or those unable to follow the study protocol may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study explores the neural mechanisms underlying cognitive decline and evaluates various cognitive assessment methods for individuals experiencing mild cognitive dysfunction. It employs functional and structural MRI and EEG to analyze brain activity and structure in participants from different cities. The study also tests multi-modal targeted interventions, including cognitive training, exercise, and games, aimed at improving and restoring cognitive function in affected individuals.
Why it matters
Potential benefit: If successful, this study could lead to effective interventions that enhance cognitive function in individuals with mild cognitive impairment and subjective cognitive decline.
How similar studies have gone: Other studies have shown promise in using cognitive training and rehabilitation approaches, suggesting potential success for this study's methodology.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults being able to walk at least a block, and * Adults with subjective cognitive decline (SCD), or * Adults with mild cognitive impairment (MCI), or * Adults with normal cognitive function Exclusion Criteria: * Clinical diagnosis of dementia * Adults who cannot follow the protocal
Where it's running
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National Research Center for Rehabilitation Technical Aids
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Principal investigator: Pengxu Wei — National Research Center for Rehabilitation Technical Aids
- Study coordinator: Ying Wang
- Email: CARM_AD@aliyun.com
- Phone: 1058122921
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.