Motor reserve in the early stages of dementia: a look at movement in people with MCI and healthy adults
Official title: Assessment of Motor Reserve in the Preclinical Stages of Dementia.
Run by Istituto per la Ricerca e l'Innovazione Biomedica · NCT07634055 · Data updated 2026-11-12
This study tests whether motor performance and movement patterns can reveal motor reserve in people with mild cognitive impairment and in healthy adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Istituto per la Ricerca e l'Innovazione Biomedica Academic / other |
| Locations | 1 site (Catanzaro, Catanzaro) |
| Status | Recruiting |
| Started | July 2026 |
| Main results expected | September 2026 |
| Study ends | July 2027 |
| Registry record updated | June 8, 2026 |
| Trial ID | NCT07634055 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 40–85 with MCI per NIA-AA criteria or cognitively healthy individuals, fluent in Italian, and able to provide informed consent.
✕Probably not a fit
Those who do not show distinct motor reserve patterns or who are outside the age range or language requirements may derive limited benefit from this research.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a monocentric observational study that uses a sensor-based device to analyze movement during a hand-focused task in individuals with MCI and in healthy controls. The aim is to characterize motor reserve and its potential role as a preclinical indicator of dementia. Participants include adults aged 40–85, with fluent Italian, who are either diagnosed with MCI or are cognitively normal. Data collection combines clinical assessment with objective kinematic measurements from the Hand Test System. Findings may help explain how motor function relates to early cognitive decline.
Why it matters
Potential benefit: If successful, the study could help identify motor-based indicators that accompany early cognitive changes and inform future strategies for early detection and monitoring of dementia.
How similar studies have gone: Previous work has explored motor symptoms in early cognitive decline, but this study applies a multidimensional motor reserve approach using a sensor-based handheld system.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with Mild Cognitive Impairment (MCI) group * Diagnosis of MCI according to the international criteria of the National Institute on Aging-Alzheimer's Association (NIA-AA) (Albert et al., 2011; McKhann et al., 2011). * Age between 40 and 85 years. * Native Italian speaker or sufficient Italian language proficiency to understand the tests. * Signed informed consent provided by the participant or by a legal representative. * Healthy subjects group * Normal performance on the neuropsychological screening assessment. Age between 40 and 85 years. * Native Italian speaker or sufficient Italian language proficiency to understand the tests. * Signed informed consent. Exclusion Criteria: * Patients with Mild Cognitive Impairment (MCI) group -History of psychiatric or neurological disorders not attributable to MCI. Use of psychotropic medications. * Healthy subjects group * History of psychiatric or neurological disorders. * Use of psychotropic medications. * Disabling medical comorbidities or medical conditions interfering with motor function.
Where it's running
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Azienda Ospedaliera "Renato Dulbecco"
Catanzaro, Catanzaro, Italy Recruiting
Study contacts
- Study coordinator: Domenico co Bosco, Medical Doctor
- Email: nico.bosco@libero.it
- Phone: 0961/883021
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.