Creatine and weight training for older adults with mild cognitive impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants aged 60 and older with mild cognitive impairment will be randomized to four groups to receive creatine with resistance training, creatine alone, resistance training alone, or placebo with no training for 26 weeks. The trial will measure visuospatial working memory as the primary outcome and also assess executive function, mobility, strength, bone density, and brain biomarkers. Brain imaging and metabolite analyses will explore changes in resting brain activity and hippocampal structure. The study aims to determine if creatine and resistance training have additive or independent benefits on cognitive and physical health in this population.

Why it matters

Who can join: the full rules

We will include participants who: 1) are aged \>60; 2) are living independently in the community; 3) have normal or corrected-to-normal vision and hearing; 4) read, write, and speak English fluently; 5) are right-handed (if participating in the MRI component); 6) have subjective feelings of memory decline in the past five years; 7) have telephone Montreal Cognitive Assessment (T-MoCA) scores \<19/22; 8) have high independence, as indicated by Instrumental Activities of Daily Living (IADL) scale \>6/8; 9) have a Geriatric Depression Scale (GDS) score \<6/15; 10) are able to exercise at a moderate pace using resistance training for 60 minutes 3x/week; and 11) receive clearance from a physician to participate in an exercise program at baseline.

We will exclude participants who: 1) cannot partake or commit to exercise training 3x/week for 26 weeks or have engaged in resistance training \>1x/week over the past three months; 2) cannot partake or commit to consuming a daily supplement for 26 weeks or have consumed nutritional supplements containing creatine monohydrate over the past three months; 3) have a known allergy to creatine monohydrate or dextrose; 4) have been diagnosed with a neurological disorder (e.g., Alzheimer's disease, Parkinson's disease); 5) have pre-existing kidney disease, heart disease, or liver abnormalities; 6) have one or more uncontrolled chronic or psychiatric conditions (e.g., hypertension, diabetes, depression, anxiety); 7) are taking medication that may impact kidney function (e.g., non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen); or 8) are ineligible or uncomfortable with blood sampling.

Where it's running

• Western University
  London, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Lindsay Nagamatsu, PhD
• Email: lnagamat@uwo.ca
• Phone: 519 661-2111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.