Cognitive function, daily independence, and mood in people with dementia or MCI.
Dementia and Mild Cognitive Impairment: Assessment of Cognitive Functioning, Functional Autonomy, and Neuropsychiatric Symptoms.
We will see how thinking abilities, independence in everyday activities, and mood change over time in people aged 50–86 with dementia or mild cognitive impairment using repeated clinic assessments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 151 (estimated) |
| Ages | 50 Years to 86 Years |
| Sex | All |
| Sponsor | IRCCS Centro Neurolesi Bonino Pulejo Academic / other |
| Locations | 1 site (Messina, ME) |
| Trial ID | NCT07287410 on ClinicalTrials.gov |
What this trial studies
This is a retrospective observational analysis of neuropsychological data from patients followed at the Neuropsychology Outpatient Clinic of IRCCS Centro Neurolesi Bonino Pulejo. Participants included have at least three test sessions roughly 12 months apart, and the protocol focuses on cognitive tests, ADL and IADL scales, and standardized measures of neuropsychiatric and mood symptoms. The primary aim is to measure functional autonomy over time, while secondary analyses examine the presence and impact of emotional and behavioral symptoms on patient well‑being. Results are intended to inform more targeted, personalized clinical management for people with dementia or MCI.
Who should consider this trial
Good fit: Adults aged 50–86 with a suspected or confirmed diagnosis of dementia or mild cognitive impairment who were referred to and completed repeated neuropsychological assessments at the IRCCS Centro Neurolesi Bonino Pulejo and who can complete testing without severe interfering behavioral, psychiatric, or sensory problems.
Not a fit: Patients with other major neurological disorders, unstable serious psychiatric comorbidities, uncorrected severe sensory deficits, or on unstable medications that significantly affect cognition are unlikely to benefit from this analysis.
Why it matters
Potential benefit: If successful, the findings could help clinicians better tailor care to preserve independence and address mood or behavioral symptoms earlier.
How similar studies have performed: Longitudinal neuropsychological and ADL/IADL studies have been performed previously and have informed clinical care, so this approach builds on established methods rather than testing a novel intervention.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 50 and 86 years. * Suspected or confirmed diagnosis of dementia or mild cognitive impairment (MCI). * Referral to the neuropsychology clinic for initial assessment or clinical monitoring. * Absence of behavioral, psychiatric, or sensory disorders severe enough to significantly impair cognitive testing or completion of questionnaires. Exclusion Criteria: * Presence of neurological disorders other than dementia or MCI (e.g., recent stroke, severe traumatic brain injury, epilepsy, multiple sclerosis, atypical neurodegenerative diseases). * Unstable major psychiatric comorbidities at the time of assessment (e.g., schizophrenia, bipolar disorder in active phase, untreated severe depression). * Uncorrected severe sensory deficits (visual or auditory) affecting the validity of cognitive or functional assessments. * Use of medications with significant cognitive impact (e.g., sedatives, high-dose antipsychotics) not stabilized at the time of evaluation. * Presence of terminal medical or oncological conditions or other illnesses significantly interfering with the assessment procedures.
Where this trial is running
Messina, ME
- Irccs Centro Neurolesi Bonino Pulejo — Messina, Me, Italy (Recruiting)
Study contacts
- Study coordinator: Francesco Corallo
- Email: francesco.corallo@irccsme.it
- Phone: 09060128335
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.