Cognitive function, daily independence, and mood in people with dementia or MCI.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective observational analysis of neuropsychological data from patients followed at the Neuropsychology Outpatient Clinic of IRCCS Centro Neurolesi Bonino Pulejo. Participants included have at least three test sessions roughly 12 months apart, and the protocol focuses on cognitive tests, ADL and IADL scales, and standardized measures of neuropsychiatric and mood symptoms. The primary aim is to measure functional autonomy over time, while secondary analyses examine the presence and impact of emotional and behavioral symptoms on patient well‑being. Results are intended to inform more targeted, personalized clinical management for people with dementia or MCI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 50 and 86 years.
* Suspected or confirmed diagnosis of dementia or mild cognitive impairment (MCI).
* Referral to the neuropsychology clinic for initial assessment or clinical monitoring.
* Absence of behavioral, psychiatric, or sensory disorders severe enough to significantly impair cognitive testing or completion of questionnaires.

Exclusion Criteria:

* Presence of neurological disorders other than dementia or MCI (e.g., recent stroke, severe traumatic brain injury, epilepsy, multiple sclerosis, atypical neurodegenerative diseases).
* Unstable major psychiatric comorbidities at the time of assessment (e.g., schizophrenia, bipolar disorder in active phase, untreated severe depression).
* Uncorrected severe sensory deficits (visual or auditory) affecting the validity of cognitive or functional assessments.
* Use of medications with significant cognitive impact (e.g., sedatives, high-dose antipsychotics) not stabilized at the time of evaluation.
* Presence of terminal medical or oncological conditions or other illnesses significantly interfering with the assessment procedures.

Where it's running

• Irccs Centro Neurolesi Bonino Pulejo
  Messina, Me, Italy Recruiting

Study contacts

• Study coordinator: Francesco Corallo
• Email: francesco.corallo@irccsme.it
• Phone: 09060128335

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.