Group exercises to improve thinking and daily lifestyle for people with mild cognitive impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with mild cognitive impairment will be enrolled and assigned to either a multimodal group cognitive rehabilitation program or an active control condition, with outcomes collected at baseline and after 12 weeks. The intervention combines group cognitive training, lifestyle strategies, and technology-supported exercises designed for clinical sustainability and accessibility. Cognitive, behavioral, and functional measures will be used to compare changes between the intervention and active control groups. The design emphasizes a pragmatic, clinic-friendly format to increase service accessibility for patients with MCI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of MCI according to the diagnostic criteria of Petersen (2004) and Winblad et al. (2004) and, if applicable (i.e., MCI due to AD), according to those of Albert and colleagues (2011).
* Self-reported basic skills in using technological devices, or access to a close person able to provide assistance.
* Willingness of the patient to report, during the study period, any changes in the dosage of psychotropic drugs or other medications that may affect cognition, such as anticholinergics, opioids, benzodiazepines, antidepressants, muscle relaxants, and antiepileptics.

Exclusion Criteria:

* Parkinson's disease.
* Linguistic single-domain MCI (suspected onset of primary progressive aphasia).
* Other neurological conditions potentially associated with cognitive impairment (e.g., previous stroke or traumatic brain injury).
* Significant laboratory abnormalities potentially associated with cognitive impairment (e.g., low levels of vitamin B12 or folate, or values indicative of thyroid disorders).
* Primary psychiatric disorders.
* Alcohol or substance use disorder in the previous 10 years.
* Severe behavioral disturbances limiting group participation.
* Hearing or visual impairments that may interfere with assessment or treatment.
* Medical conditions that may interfere with completion of the study.
* Exposure, during the study period, to other neuropsychological rehabilitation interventions.
* Patient's refusal to sign the informed consent.

Where it's running

• Casa di Cura Igea
  Milan, Milan, Italy Recruiting
• Casa di Cura Igea
  Milan, Milano, Italy Not yet recruiting

Study contacts

• Principal investigator: Sabrina Guzzetti — Casa di Cura Igea, Milano
• Study coordinator: Sabrina Guzzetti Neuropsychologist
• Email: s.guzzetti@casadicurigea.it
• Phone: +390248593315

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.