Condition

Subjective Cognitive Decline (SCD) clinical trials and research

• 26Clinical trials
• 2New in 30 days
• 23Countries

Newest Subjective Cognitive Decline (SCD) clinical trials

All recruiting trials (26)

• Daily-life Virtual Reality Training to Support Thinking and Daily Tasks in adults 50 and older

  A touchscreen-based daily-life VR program is being tested to see if it helps people 50+ improve daily activities and thinking skills, especially for those at risk of dementia.

  Recruiting National Taiwan University Hospital · Taipei · NCT07895979

• Aging Brain Health Initiative in Fujian

  This observational study will follow about 3,000 older adults in Fujian to see how Alzheimer's-related changes develop and to test new digital tests, biomarkers, and imaging tools for early diagnosis.

  Recruiting at 4 sites Fujian Medical University Union Hospital · Fushun, Fujian and 3 other locations · NCT07891429

• Longitudinal profiling of plasma-derived glial extracellular vesicles in Alzheimer's disease

  This study tests whether plasma glial extracellular vesicles and neuroinflammation biomarkers change over time across the Alzheimer’s disease spectrum and whether these signals relate to amyloid, tau, and neurodegeneration, with an additional step of exposing healthy iPSC-derived neurons to vesicles to see potential ne

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT07803055

• Digital tools to predict Alzheimer's biology from risk factors

  This study tests a digital, AI-based tool that analyzes modifiable and non-modifiable risk factors to see if it can predict biological changes linked to Alzheimer's disease in adults with MCI or SCD.

  Recruiting at 2 sites IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia, BS and 1 other locations · NCT07731191

• Personalized Brain Health Service for Dementia Prevention in People with Subjective Cognitive Decline

  This study tests a personalized Brain Health Service to see if tailored risk assessment and a 6‑month lifestyle program can lower dementia risk for people aged 55–85 who have subjective cognitive concerns.

  Recruiting Barcelonabeta Brain Research Center, Pasqual Maragall Foundation · Barcelona, Catalonia · NCT07698431

• Virtual reality-based cognitive and physical rehab for people with mild cognitive impairment or subjective cognitive decline

  This study tests whether VR-based cognitive and physical rehabilitation is feasible, usable, and acceptable for people with mild cognitive impairment or subjective cognitive decline.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT07638748

• Chinese Classics recitation training for people with subjective memory concerns

  A 6-month program of Chinese Classics recitation is being tested to see if it helps people aged 60+ who notice memory problems but don’t have measurable impairment.

  Recruiting China Medical University Hospital · Taichung · NCT07463391

• Lombardy Brain Health Services cohort

  This project will see if a blood biomarker (pTau-217), together with clinical and cognitive tests, can help distinguish adults in Lombardy who have subjective cognitive decline, functional cognitive disorder, or are worried about their thinking.

  Recruiting at 3 sites University of Milano Bicocca · Costa Masnaga, Lombardy and 4 other locations · NCT07457138

• Finding signs of Alzheimer's in people with subjective memory complaints

  The study will test whether inexpensive, easy-to-get measures—like blood markers, EEG and automated speech analysis—can help identify early Alzheimer's in people who notice memory or thinking changes but have normal standard tests.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milan · NCT07402161

• See if three months of visual flicker at 16.67 Hz helps cognition and mood in older adults with or without subjective cognitive concerns

  This study tests whether three months of flicker stimulation three times a week can improve thinking, movement, and mood in healthy older adults and those with subjective cognitive decline.

  Recruiting University of Florida · Gainesville, Florida · NCT07395609

• Spermidine to improve sleep and memory in mild cognitive impairment

  This will see if taking daily spermidine supplements for 12 weeks improves sleep quality and sleep-related memory in older adults with MCI due to Alzheimer's disease.

  Recruiting University Medicine Greifswald · Greifswald, Mecklenburg-Vorpommern · NCT07383311

• Online positive psychology program to support thinking and brain health in early memory changes

  This study will test whether an online positive psychology program can improve thinking, brain function, and wellbeing in older adults with early memory problems (Subjective Cognitive Decline or Mild Cognitive Impairment).

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki · NCT07289061

• Personalized digital training for cognitive fitness in people with mild cognitive impairment

  This study tests whether a personalized home-based digital program (RICORDO) helps people aged 50 and older with mild cognitive impairment or subjective cognitive decline manage their health and daily life better than a paper-and-video education program.

  Recruiting at 2 sites University of Modena and Reggio Emilia · Modena, Reggio Nell'Emilia (RE) and 1 other locations · NCT07286448

• NPC-1 (parthenolide and ipriflavone) for Alzheimer's blood biomarkers

  This trial will test whether taking NPC-1 (a combination of parthenolide and ipriflavone) is safe, well tolerated, and changes blood tests linked to Alzheimer's in adults 55+ with subjective cognitive decline, mild cognitive impairment, or mild Alzheimer's who have biomarker evidence of disease.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT07236190

• InRAD international registry for Alzheimer's disease and related dementias

  This project will collect routine medical information over time to see how Alzheimer's disease, mild cognitive impairment, and related dementias progress and how current treatments are tolerated in adults.

  Recruiting at 23 sites Stichting International Registry for Alzheimer's Disease and other Dementias Foundation · Melbourne and 22 other locations · NCT07213700

• Accelerated deep TMS to boost memory and thinking in older adults with mild memory problems

  We will test whether a short, intensive course of deep transcranial magnetic stimulation to the anterior cingulate plus online cognitive training can improve memory and thinking in people aged 55–85 with mild cognitive impairment or subjective memory decline.

  Recruiting Rotman Research Institute at Baycrest · Toronto, Ontario · NCT07212504

• FACE Phase II: Facial-expression personalization for at-home cognitive training

  This project tests whether a facial-expression personalization system can track and adjust real-time engagement to improve adherence to home-based computerized cognitive training for older adults at risk for Alzheimer's disease.

  Recruiting Phase 1/2 Stanford University · Palo Alto, California · NCT07130669

• Boosting physical activity with tech, social support, and stress resilience

  This study tests whether adding technology-based tools plus social support and stress-resilience activities helps older adults living alone with subjective cognitive decline become more physically active.

  Recruiting Arizona State University · Phoenix, Arizona · NCT06896825

• Korean Joint Registry for Alzheimer's Treatment and Diagnostics

  This study is testing new Alzheimer's treatments, like lecanemab and donanemab, to see how well they work and are safe for people with Alzheimer's in South Korea.

  Recruiting at 2 sites Ewha Womans University Mokdong Hospital · Incheon and 2 other locations · NCT06889818

• Olfactory Network Testing with Electro-acupuncture for Subjective Cognitive Decline

  This study tests whether electro-acupuncture can help people aged 55–79 with subjective cognitive decline, by looking at changes in their brain’s smell-related networks.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06758154

• Validation of Italian cognitive assessment scales for elderly patients

  This study is trying to see if new Italian versions of cognitive and daily living assessments can help doctors better diagnose neurodegenerative diseases in older Italian-speaking patients.

  Recruiting Casa di Cura IGEA · Milan, Michigan · NCT06701630

• Improving sleep in older adults with mild cognitive impairment using brain stimulation and CBT-I

  This trial will try combining gentle transcranial magnetic stimulation (TMS) with cognitive behavioral therapy for insomnia (CBT-I) to improve sleep in people aged 60 and older who have mild cognitive impairment or subjective cognitive decline.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT06687161

• Improving sleep quality to enhance memory in older adults with mild cognitive impairment

  This study is testing whether using special sounds during sleep can help older adults with mild memory problems sleep better and improve their memory over time.

  Recruiting University of Bern · Bern · NCT06669546

• A program to engage people with memory challenges in outdoor activities

  This study is testing a new outdoor activity program for people with memory challenges and their partners to see if it helps them feel better and enjoy nature more.

  Recruiting Indiana University · Bloomington, Indiana · NCT06403345

• Investigating brain mechanisms for cognitive assessment and rehabilitation in cognitive decline

  This study is testing different ways to improve thinking skills in people with mild cognitive decline by looking at brain activity and trying out activities like training, exercise, and games.

  Recruiting National Research Center for Rehabilitation Technical Aids · Beijing, Beijing Municipality · NCT05014893

• Comprehensive assessment of neurodegeneration and dementia

  This project will collect brain scans, cognitive tests, and biological samples over time to see how dementia and related conditions progress in adults aged 50–90, including people with Parkinson's and people without cognitive problems.

  Recruiting at 11 sites McGill University · Calgary, Alberta and 18 other locations · NCT03402919

Related topics

Quick answers

How many Subjective Cognitive Decline (SCD) clinical trials are recruiting right now?

26, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 23 countries. The most sites are in United States (7 trials), Italy (7 trials), Taiwan (3 trials), China (3 trials), Greece (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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