Genetic factors in early-onset dementia
Genetic Studies of Early-onset Dementia
This study is trying to find out how genetics might affect the risk and progression of early-onset dementia by looking at people with dementia, their families, and healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 35 Years and up |
| Sex | All |
| Sponsor | Columbia University Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT04906863 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify genetic factors that contribute to the risk and progression of early-onset dementia, including Alzheimer's Disease and mild cognitive impairment. It involves individuals diagnosed with dementia, their family members, and cognitively healthy controls. Participants will undergo blood draws, neurocognitive testing, and complete medical questionnaires to gather comprehensive data across diverse ethnic groups. The study seeks to enhance understanding of the genetic underpinnings of early-onset dementia.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 18 and older diagnosed with early-onset dementia, their family members, and unrelated healthy controls without dementia.
Not a fit: Patients with competing diagnoses such as Huntington's disease, traumatic brain injury, or schizophrenia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of genetic risks for early-onset dementia, potentially guiding prevention and treatment strategies.
How similar studies have performed: Other studies have shown success in identifying genetic factors related to dementia, making this approach both relevant and promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * 35 years and older * Individuals experiencing memory concerns or diagnosed with dementia and their family members that are unrelated healthy controls without dementia. Exclusion Criteria: \- Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual
Where this trial is running
New York, New York
- Columbia University Irving Medical Center — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Christiane Reitz, MD, PhD — Columbia University
- Study coordinator: Pamela Del Rosario
- Email: pd2727@cumc.columbia.edu
- Phone: 212-304-7284
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.