Inspiratory muscle training to try to improve thinking and physical function in mild cognitive impairment
Official title: The Effect of Strengthening Respiratory Muscles on Cognitive and Physical Functioning in Patients With Neurocognitive Disorders
Run by University of West Attica · NCT07146373 · Data updated 2026-11-12
This project will try a targeted breathing (inspiratory muscle) training program to see if it helps thinking and physical abilities in people with mild cognitive impairment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years to 90 Years |
| Sex | All |
| Enrollment | 76 (estimated) |
| Sponsor | University of West Attica Academic / other |
| Locations | 1 site (Aigáleo, Attica) |
| Status | Recruiting |
| Started | March 1, 2025 |
| Main results expected | December 30, 2027 |
| Study ends | May 30, 2028 |
| Registry record updated | August 28, 2025 |
| Trial ID | NCT07146373 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with mild cognitive impairment (MMSE 18–28) who are medically stable on their current medications and can attend supervised training sessions are ideal candidates.
✕Probably not a fit
People with MMSE scores below 18 or above 28, those with active psychological disorders or contraindications to physical training, or those unable to attend in-person sessions are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares a high-intensity inspiratory muscle training (IMT) program delivered alongside a physical-cognitive training program to the physical-cognitive program alone or usual care in people with mild cognitive impairment. Eligible participants (MMSE 18–28) will attend supervised IMT sessions at the University of West Attica and complete baseline and follow-up cognitive and physical performance tests. The IMT intervention focuses on respiratory muscle strengthening delivered over multiple sessions, with feasibility, cognitive test scores, and physical function measures recorded. Results will show whether adding IMT is practical for this population and whether it produces measurable cognitive or physical benefits.
Why it matters
Potential benefit: If successful, IMT could improve thinking and daily physical abilities in people with mild cognitive impairment and provide a low-risk rehabilitation option.
How similar studies have gone: Some small studies of respiratory training or exercise suggest cognitive or functional benefits, but the use of IMT specifically for mild cognitive impairment is relatively novel with limited direct evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * MMSE (Mini Mental State Examination) score ≤ 28 και ≥ 18 * stable treatment related to medication Exclusion Criteria: * MMSE score \< 18 και \> 28 * psychological disorder * any contraindication to physical training
Where it's running
-
University of West Attica
Aigáleo, Attica, Greece Recruiting
Study contacts
- Principal investigator: IRINI PATSAKI, PhD — University of West Attica
- Study coordinator: IRINI PATSAKI, PhD
- Email: ipatsaki@uniwa.gr
- Phone: +306942064363
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.