Condition

Menopause clinical trials and research

• 67Clinical trials
• 68NIH research projects
• 1New in 30 days
• 22Countries

Newest Menopause clinical trials

All recruiting trials (67)

• Hop extract vs soy isoflavone for menopausal symptoms

  This study tests whether a full-spectrum hop extract helps reduce menopausal mood symptoms better than soy isoflavones in peri- and postmenopausal women.

  Recruiting Menoclinica by Palacios · Madrid, Madrid · NCT07904390

• Resveratrol and Estrogen Receptors in Postmenopausal Women with CAD

  This study tests whether taking resveratrol is safe and can change estrogen-related markers in postmenopausal women with coronary artery disease.

  Recruiting InCor Heart Institute · São Paulo, São Paulo · NCT07865377

• Ashoka Bark and Shatavari for Menopause

  This 12-week study tests whether a daily Ashoka Bark and Shatavari supplement helps reduce menopausal symptoms in postmenopausal women compared with a placebo.

  Recruiting Vidya USA Corporation · New Port Richey, Florida · NCT07861295

• Lifestyle changes to ease menopausal symptoms, sleep problems, and anxiety

  Researchers are testing whether a structured lifestyle education program helps perimenopausal and postmenopausal women see fewer menopausal symptoms, better sleep, and less anxiety compared to usual care.

  Recruiting Konya Beyhekim Training and Research Hospital · Konya, Konya · NCT07860645

• Pain and period life: does menstrual cycle or menopause change pain during root canals?

  This study will see if pain during a root canal varies with menstrual cycle phase or menopausal status in adult patients.

  Recruiting Nigde Omer Halisdemir University · Niğde · NCT07850167

• Sex hormones, menopause, and exercise in aging women

  This study tests how hormonal status and resistance training affect age-related muscle and nerve function in postmenopausal women.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07848438

• Shatavari-based herbal extract to help menopausal symptoms

  This study tests whether an 8-week daily herbal extract containing Shatavari can reduce menopausal symptoms in postmenopausal women, compared with a placebo.

  Recruiting India Glycols Ltd · New Port Richey, Florida · NCT07834463

• Cyclic vs. Constant Estradiol for Brain Health in Menopause

  This study tests whether cyclic or continuous estradiol patches improve brain health and wellbeing in healthy postmenopausal adults.

  Recruiting Phase 4 University of Colorado, Denver · Aurora, Colorado · NCT07831499

• Dietary guidelines-based eating plan to reduce menopausal symptoms in overweight and obese women

  A randomized trial will test whether following healthy eating guidance from Brazil’s dietary guidelines can lessen menopausal symptoms in women who are overweight or obese.

  Recruiting Federal University of Health Science of Porto Alegre · Porto Alegre, Rio Grande do Sul · NCT07822230

• Breast and Blood Vessel Effects of Menopause Hormone Therapy in Postmenopausal Women

  This observational study will see if systemic menopause hormone therapy changes breast density and carotid artery thickness over 12 months in postmenopausal women.

  Recruiting Sanliurfa Mehmet Akif Inan Education and Research Hospital · Bursa · NCT07810959

• What predicts religious orientation attitudes in menopausal women

  This study tests whether how severe menopausal symptoms and beliefs about sexual myths relate to intrinsic religious orientation in healthy women going through menopause.

  Recruiting KTO Karatay University · Konya · NCT07797296

• Estradiol/Levonorgestrel Transdermal System safety in healthy postmenopausal women

  This study tests whether the Estradiol/Levonorgestrel Transdermal System causes skin irritation or allergic reactions in healthy postmenopausal women, compared with Climara Pro patches.

  Recruiting Phase 1 Corium Innovations, Inc. · Las Vegas, Nevada and 1 other locations · NCT07794150

• Haelan 951 for menopause symptoms in peri- and postmenopausal women

  This open-label study tests daily Haelan 951, a fermented soy product, to see if it helps with hot flashes, sleep, and quality of life in peri- and postmenopausal women.

  Recruiting Spectrum Clinical Research, LLC · Kansas City, Missouri · NCT07751029

• CARAMEL: Personalizing Heart Risk in Women 40–60

  This observational study tests a personalized cardiovascular risk-stratification approach for women aged 40–60 using multi-source data and a digital self-management tool.

  Recruiting at 3 sites Biogipuzkoa Health Research Institute · Bogotá and 5 other locations · NCT07695376

• Samphire Guided Care for Wellbeing at Work

  This study tests a 12-week digital program with at-home neuromodulation to see if it helps women with menstrual or perimenopausal symptoms feel better at work and in daily life.

  Recruiting Samphire Group, Inc. · San Francisco, California · NCT07679074

• Beta3-adrenergic Receptors and Vascular Function in Aging Women

  This trial tests whether activating beta3-adrenergic receptors can improve blood vessel function in aging women undergoing menopause.

  Recruiting Early Phase 1 University of Missouri-Columbia · Columbia, Missouri · NCT07674680

• Estrogen status and muscle health in aging women before and after menopause

  This study tests how estrogen levels relate to muscle size, strength, and function in women around menopause.

  Recruiting University of Aarhus · Aarhus · NCT07649356

• MenoZen VR for managing menopause symptoms

  This study tests whether MenoZen VR can help reduce hot flashes and other menopause symptoms in women aged 45–60 who have frequent hot flashes and can use a computer or smartphone at home.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07633743

• MicroRNA and bone markers linked to response to romosozumab and abaloparatide in postmenopausal osteoporosis

  Researchers will test whether microRNA and other bone markers can predict how well postmenopausal women with osteoporosis respond to romosozumab and abaloparatide.

  Recruiting Istituto Auxologico Italiano · Miano, Lombardy and 1 other locations · NCT07616401

• AGEWISE: Exploring how the gut microbiome and hormones change as women age

  This study will look at how the gut microbiome relates to hormonal changes during menopause in healthy women aged 40–64 in Portugal to see if biomarkers can help predict health risks.

  Recruiting Gulbenkian Institute for Molecular Medicine · Lisbon · NCT07614542

• Avatar-based education and counseling to boost spousal support during menopause

  Ages 45-60 menopausal women and their spouses will try an online avatar-based education and counseling program to see if it increases spousal support compared with routine care.

  Recruiting Eskisehir Osmangazi University · Bursa · NCT07599319

• Adherence to a creatine-based nutritional supplement in estrogen-depleted women

  This 12-week observational project will test how well estrogen-depleted women stick to taking a creatine-based nutritional supplement.

  Recruiting at 3 sites Margan Biotech · Madrid, Madrid and 3 other locations · NCT07580846

• Vaginal DHEA vs Vaginal Estrogen for Menopause Symptoms

  This study tests whether vaginal DHEA or vaginal estrogen helps with vaginal dryness, discomfort, and urinary symptoms in peri- or post-menopausal women by randomly assigning participants to one treatment and measuring their symptoms over time.

  Recruiting University of Arizona · Phoenix, Arizona · NCT07574216

• Menopause-related changes in brain-to-spine motor pathways with hormone therapy

  This project will test whether starting combined hormone replacement therapy changes brain-to-muscle signaling, strength, body composition, and metabolism in women within five years of menopause.

  Recruiting University of Jyvaskyla · Jyväskylä · NCT07500922

• Low-level laser acupuncture to improve body shape and composition in overweight menopausal women

  This trial will test whether adding low-level multi-acupoint laser acupuncture to WHO-recommended diet and exercise helps overweight or obese menopausal women lose weight and improve body composition.

  Recruiting Chang Gung Memorial Hospital · Keelung, Taiwan · NCT07472881

• Hemp-derived cannabinoids for menopause and perimenopause symptom relief

  This will try hemp-derived cannabinoids versus placebo to see if they reduce physical and psychological symptoms in women aged 40–60 going through perimenopause or menopause.

  Recruiting Phase 2 Washington State University · Pullman, Washington · NCT07393672

• 16:8 time-restricted eating with a low glycaemic-index Mediterranean diet for perimenopausal and menopausal women

  This trial will test whether a 16:8 time-restricted eating schedule combined with a low glycaemic-index Mediterranean diet can improve thinking, metabolic health, and biological ageing in women aged 45–75 in late perimenopause or menopause with BMI ≥23.

  Recruiting University of Nicosia · Zagreb and 1 other locations · NCT07378787

• Blackcurrant supplementation to test bone density changes in postmenopausal women

  This study tests whether taking blackcurrant extract can help improve bone density in postmenopausal women by affecting the gut microbiome.

  Recruiting Phase 1 University of Connecticut · Storrs, Connecticut · NCT07365514

• Probiotic drink for skin inflammation during the menopausal transition

  This study will test whether a daily Lactobacillus casei Shirota probiotic drink can reduce inflammation and improve immune and skin health in women aged 40–60 going through the menopausal transition with inflammatory facial skin conditions.

  Recruiting King's College London · London, London · NCT07341087

• How menopause and HIV together affect cardiovascular disease risk in women.

  This study will see if menopause combined with HIV raises heart disease risk in women with HIV by examining risk factors, inflammation, body composition, and whole-body MRI.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07284082

• Can menopausal hormone therapy affect heart function after menopause?

  This study tests whether menopausal hormone therapy changes how the heart responds to stress in women who are past menopause.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07242391

• Equol's effect on menopausal symptoms in Singaporean women

  This project will test if making equol after eating a soy protein bar helps lessen menopausal symptoms in Singaporean women aged 40–60.

  Recruiting KK Women's and Children's Hospital · Singapore · NCT07136220

• Resistance training with a plant-based supplement for perimenopausal symptoms and muscle health

  This trial tests whether a plant-based supplement (sarmentosin + L-theanine), resistance training, or the combination can help perimenopausal women with mood, sleep, cognition, strength, and muscle mass.

  Recruiting Leeds Beckett University · Leeds, North Humberside · NCT07135232

• Smartphone-guided exercise and monitoring for early postmenopausal women

  This trial will test whether an 8-week, smartphone-delivered multimodal exercise program helps early postmenopausal women improve quality of life, muscle strength, and physical performance.

  Recruiting National Cheng Kung University · Tainan · NCT07131215

• Understanding menopause, brain energy, and thinking

  This observational study looks at how the menopausal transition affects brain energy use and thinking skills in women.

  Recruiting Université de Sherbrooke · Sherbrooke, Quebec and 1 other locations · NCT07021664

• Brazilian Registry of Menopausal Health

  This study tests how health, knowledge, and quality of life during menopause vary by region and socioeconomic factors in people aged 35 to 65 who are in the menopausal transition or postmenopause.

  Recruiting Science Valley Research Institute · São Paulo, São Paulo · NCT07005648

• Improving midlife women's health during the menopausal transition

  This study will test whether medicines (metformin, semaglutide, blood pressure and cholesterol drugs) combined with lifestyle changes can reduce bothersome menopausal symptoms and lower future heart and metabolic disease risk in women aged 45–55 who are in the late menopausal transition.

  Recruiting at 3 sites Phase 2/3 University of Colorado, Denver · Aurora, Colorado and 2 other locations · NCT06975111

• Online therapy for anxiety in women going through menopause

  This study is testing an online therapy program to see if it can help women going through menopause feel less anxious.

  Recruiting at 2 sites Queen's University · Kingston, Ontario and 1 other locations · NCT06865066

• Hormone therapy for hot flashes in women living with HIV

  This study tests whether transdermal estradiol (with or without progesterone) can relieve hot flashes and improve quality of life for women living with HIV who are going through menopause.

  Recruiting at 23 sites Phase 4 Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Birmingham, Alabama and 22 other locations · NCT06856174

• Time-restricted eating for menopausal women and those on hormone therapy for breast cancer

  This trial will test whether eating only during an 8-hour window each day (16:8 time-restricted eating) helps overweight menopausal women and women taking aromatase inhibitors manage weight and symptoms.

  Recruiting University Hospital, Geneva · Geneva, Canton of Geneva · NCT06855784

• Using wearable data to improve cardiovascular risk predictions in women

  This study is testing if information from wearable devices can help better predict heart disease risk in women aged 40-69 when usual health measurements aren't available.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06831890

• Understanding how menopause affects body temperature regulation

  This study tests how menopause affects body temperature control in women aged 42-64 by comparing responses to heat in those with low estrogen and those with higher estrogen levels.

  Recruiting Phase 4 Penn State University · University Park, Pennsylvania · NCT06798571

• How sympathetic nerve signals affect blood vessels during the menopause transition

  This will test whether medicines that block sympathetic nerve signals change blood flow responses in women before, during, and after menopause.

  Recruiting Early Phase 1 University of Missouri-Columbia · Columbia, Missouri · NCT06787066

• Breathing muscle training to help midlife women with menopause symptoms

  This study is testing if breathing exercises can help women aged 45-60 feel better during menopause by reducing hot flashes and improving sleep quality.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06743269

• Using Shatavari to treat menopausal symptoms in women

  This study is testing if Shatavari can help women aged 45 to 65 feel better during menopause by reducing symptoms like hot flashes and mood swings.

  Recruiting SF Research Institute, Inc. · San Francisco, California · NCT06716554

• Telerehabilitation program for improving sexual function and reducing pain in menopausal women

  This study is testing a telerehabilitation program to see if it can help menopausal women with painful sex feel better and improve their overall quality of life compared to regular in-person therapy.

  Recruiting Instituto Médico Tecnológico SL · Barcelona, Spain · NCT06710002

• Hormone therapy's effect on liver disease in postmenopausal women

  This study is testing if hormone replacement therapy can help postmenopausal women with liver disease by looking at how it affects liver fat and overall health.

  Recruiting Phase 1 University of Oxford · Oxford, Oxfordshire · NCT06704516

• Evaluating treatments for joint pain in menopausal women

  This study is testing whether muscle strengthening exercises, estrogen therapy, or a combination of both can help relieve joint pain in women going through menopause.

  Recruiting Phase 2/3 National University Hospital, Singapore · Singapore · NCT06530459

• Nitrate and Exercise for vascular health in midlife women

  This study tests whether daily beetroot juice (nitrate) plus regular aerobic exercise improves blood vessel function and blood pressure in postmenopausal women.

  Recruiting University of Vienna · Vienna, State of Vienna · NCT06527248

• End sleepless nights during perimenopause.

  This trial will test whether hormone replacement therapy or weekly cognitive behavioral therapy for insomnia helps perimenopausal women with insomnia sleep better than weekly sleep-hygiene advice.

  Recruiting Phase 4 Insel Gruppe AG, University Hospital Bern · Bern · NCT06497894

• Understanding how menopause affects heart and blood vessel function

  This study looks at how going through menopause affects heart and blood vessel function in women aged 45-55.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06490146

• Virtual registry for menopause and perimenopause in Australia

  This study is creating an online registry to collect information from Australian women about their experiences with menopause and perimenopause to help improve healthcare and support for them.

  Recruiting Bespoke Clinical Research · Adelaide · NCT06487130

• Beetroot nitrate plus exercise intensity for heart and fitness in postmenopausal women

  This project will test whether adding inorganic nitrate (beetroot juice) to moderate or high-intensity exercise improves vascular health and fitness in sedentary postmenopausal women.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06480695

• Probiotic to reduce menopausal symptoms

  This trial will test whether a probiotic blend can boost recycling of active estrogens and reduce hot flashes and night sweats in perimenopausal and early postmenopausal women.

  Recruiting Community Pharmacology Services Ltd · Glasgow, Glasgow · NCT06446869

• Program to help women manage menopausal symptoms

  This study tests a program that helps women manage their menopausal symptoms through exercise and education to improve their overall well-being.

  Recruiting University of Valencia · Valencia and 1 other locations · NCT06419972

• Examining how aging and menopause affect blood vessel responses to low oxygen levels

  This study is testing how aging and menopause affect blood vessel responses to low oxygen levels in women by trying different medications to see how they help.

  Recruiting Early Phase 1 University of Missouri-Columbia · Columbia, Missouri · NCT06417177

• Subdermal estradiol and testosterone implants for relieving menopausal symptoms

  This project will try bioabsorbable subdermal estradiol and testosterone implants in women with menopause-related estrogen and testosterone deficiency to see if they reduce menopausal and sexual symptoms.

  Recruiting Phase 3 University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06343870

• Effects of menopause on artery health and fat gain in women

  This study is testing how menopause and lower estrogen levels affect artery health and belly fat in women, and whether using an estrogen patch can help improve these issues.

  Recruiting Phase 4 University of Colorado, Denver · Aurora, Colorado · NCT06264882

• Investigating how menopause affects blood cell function and cardiovascular risk

  This study is testing how menopause affects blood cells and heart health in both men and women to see if hormone changes increase cardiovascular risks, especially looking at the role of hormone replacement therapy.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT05985447

• Understanding how menopause affects heart disease risk

  This study is trying to see how menopause affects heart disease risk in women by following them for at least 10 years and looking at changes in their heart and blood vessels.

  Recruiting University of Copenhagen · Copenhagen · NCT05647876

• Examining the cardiovascular effects of hot flushes in postmenopausal women

  This study tests how hot flushes affect heart and breathing responses in postmenopausal women to see if symptoms and body fat impact these effects.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05251324

• Investigating hot flashes and their impact on women's vascular health

  This study is testing how hot flashes might affect women's heart and blood vessel health, especially during menopause, to see if they increase the risk of high blood pressure and heart disease.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05193968

• Impact of Duavive on mood and anxiety in menopausal women

  This study is testing if a new hormone treatment can help improve mood and reduce anxiety in women going through menopause.

  Recruiting Phase 1 St. Joseph's Healthcare Hamilton · Hamilton, Ontario · NCT04478305

• Impact of early menopause on blood pressure regulation in women

  This study is trying to see how early menopause affects blood pressure control in women aged 35 to 70 by comparing those who went through menopause early with those who haven’t.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04439370

• Observational study on women's menstrual health using an app

  This study is trying to learn more about women's menstrual health and related conditions by having women use an app to share their experiences.

  Recruiting Apple Inc. · Boston, Massachusetts · NCT04196595

• Effects of menopause and aging on weight gain and fat distribution

  This study is testing how menopause affects weight gain and belly fat in women by looking at hormones and seeing if adjusting these hormones can help reduce fat.

  Recruiting Phase 4 University of Colorado, Denver · Aurora, Colorado · NCT04043520

• Using PRP injections to restore ovarian function in menopausal women

  This study is testing whether PRP injections can help restore ovarian function in menopausal women and improve their hormone levels.

  Recruiting Phase 2/3 Genesis Athens Clinic · Athens · NCT03916978

NIH-funded research (newest 40 of 68)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how vaginal tissue changes after menopause affect reproductive health

  A research team is studying why the vaginal lining changes after menopause and how this affects health, with potential solutions to improve comfort and reduce infection risk for postmenopausal women.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11570238

• Menopause, hormones, and Alzheimer’s disease: an in vivo perspective

  This project explores how hormone therapy around menopause might influence the risk of developing Alzheimer's disease in postmenopausal women.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11531378

• PREMAP: Predictors of Menopause-Related Psychosis

  A study to understand what factors predict psychosis that can occur during menopause, with a focus on women going through that transition.

  NIH research Yale University · New Haven, United States · NIH-11520455

• How vaginal lipids, antioxidants, and protective molecules affect menopause-related genitourinary symptoms across races

  Researchers are tracking vaginal and blood chemicals in postmenopausal women of different races to learn how lipid, antioxidant, and osmoprotectant molecules relate to genitourinary menopause symptoms.

  NIH research Mc Laughlin Research Institute · Great Falls, United States · NIH-11470677

• Menopause, Hormone Therapy, and HIV Risk in Cervical M mucosa

  This project looks at how menopause and menopause hormone therapy may change the immune guard in the cervix, potentially affecting HIV risk for aging women.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11470603

• Menopause, brain health, and aging: how hormones shape risk for dementia

  This project looks at how menopause and hormone therapy affect brain aging and dementia risk in women.

  NIH research New York University School of Medicine · New York, United States · NIH-11449501

• Reproductive events, menopause, and aging in Latina women

  This project follows Latina women to understand how puberty, pregnancy, and menopause relate to aging and late-life health risks.

  NIH research Emory University · Atlanta, United States · NIH-11447851

• Menopause, aging and brain health: how midlife changes affect Alzheimer’s risk

  This study follows women who were part of a large midlife health study to see how menopause and related factors relate to brain biomarkers and memory later in life.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11447728

• Understanding tendon aging and menopause in a mouse model

  A study using a mouse model to uncover why tendon injuries are more common and harder to heal in aging, especially after menopause.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11447098

• History of high blood pressure during pregnancy and heart risk in menopause

  This research looks at whether women who had high blood pressure problems during pregnancy have higher heart disease risk during and after menopause.

  NIH research University of Washington · Seattle, United States · NIH-11431384

• Timing of Menopausal Hormone Therapy to Protect Brain Health in Perimenopause

  A research program uses AI and real-world data to understand how menopausal hormone therapy affects brain health and Alzheimer’s risk in women around menopause.

  NIH research University of Arizona · Tucson, United States · NIH-11423210

• Timing of Menopausal Hormone Therapy and Brain Biomarkers in Women at Risk for Alzheimer's Disease

  This study explores whether starting menopausal hormone therapy during a key window can influence brain markers and risk of Alzheimer's in women who are perimenopausal or postmenopausal.

  NIH research University of Arizona · Tucson, United States · NIH-11423209

• Timing of menopausal hormone therapy and brain aging in Alzheimer's risk

  A research program is exploring how menopause-era hormone therapy affects brain aging and biomarkers related to Alzheimer's risk in women.

  NIH research University of Arizona · Tucson, United States · NIH-11423208

• Timing of Hormone Therapy and Brain Health in Perimenopause

  A study looking at how the timing and type of menopausal hormone therapy affect brain metabolism related to Alzheimer’s risk in women going through perimenopause.

  NIH research University of Arizona · Tucson, United States · NIH-11423207

• Timing of Menopausal Hormone Therapy and Brain Aging in Women at Risk for Alzheimer's Disease

  This NIH grant explores how the timing of hormone therapy during perimenopause affects brain aging and Alzheimer's risk in women.

  NIH research University of Arizona · Tucson, United States · NIH-11423206

• Menopause, Blood Vessels, and Brain Health in Aging Women

  A large study in aging women will follow them over time to see how menopause and blood vessel health relate to brain aging and risk of dementia.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11421745

• Menopause, aging, and everyday functioning in women

  A long-term study following 3,302 diverse women to understand how the menopause transition affects health and daily functioning as they age.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11421739

• Menopause, hot flashes, and heart health in midlife women

  This study looks at how menopause-related hot flashes may connect to heart disease risk in midlife women and whether treating hot flashes can improve heart health.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11403859

• B cell estrogen signaling and menopause-related metabolic problems

  How the loss of estrogen after menopause affects fat tissue and metabolic health through B cells, and whether this pathway could be targeted to help with diabetes risks.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11388595

• Understanding how aging and the vaginal microbiome affect GSM and its prevention or treatment

  This grant studies how aging-related changes in the vaginal environment and 16S microbial communities influence genitourinary syndrome of menopause (GSM) and how to prevent or treat it.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11374959

• Protective and Risk Factors for Cognitive Function in the Menopause Transition

  This grant explores how lifestyle, sleep, and cardiometabolic factors affect thinking and memory during menopause to help women maintain cognitive health.

  NIH research University of Kansas Lawrence · Lawrence, United States · NIH-11372877

• Spatial mapping of brain chemistry in aging female macaques and menopause

  A Duke University project studies how aging and menopause affect brain chemicals and proteins in female macaques to shed light on Alzheimer's disease in people.

  NIH research Duke University · Durham, United States · NIH-11371105

• Menopause, Heart Microvessels, and Women’s Health

  This research will explore why menopause increases risk for heart problems by studying tiny heart blood vessels and how they change in perimenopause and after menopause.

  NIH research University of Florida · Gainesville, United States · NIH-11366171

• Menopause, hormones, and blood pressure in women

  This grant explores how menopause and hormone changes affect blood pressure and the body's heart-blood vessel system in women.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11341862

• Regenerative biomaterial to help GSM in menopausal women

  A new, low-cost patch-like gel made from vaginal tissue material is being tested to repair thinning vaginal tissue and relieve symptoms of genitourinary syndrome of menopause in perimenopausal and menopausal women.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11327363

• Menopause and brain health in aging women

  A long-term study follows women through menopause to see how hormonal changes affect brain structure, function, and thinking.

  NIH research Washington University · Saint Louis, United States · NIH-11321217

• Smartwatch-based monitoring to improve hormone replacement therapy for menopause

  A smartwatch-based program tests whether real-time tracking can help optimize hormone replacement therapy for menopausal symptoms and potentially reduce cognitive risks.

  NIH research Amissa, INC. · Charlotte, UNITED STATES · NIH-11316421

• Timed sleep and light to improve mood during menopause

  This project tests whether timed sleep and light treatments that shift the body clock can improve mood and sleep in women going through perimenopause who are depressed.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11303378

• Menopause and brain aging in female mice

  A study using mice to explore how menopause-related hormonal changes affect brain aging in females.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11303182

• PhytoSERM: A brain-friendly estrogen approach to protect cognition in menopausal women

  A Phase 2 trial tests a plant-based estrogen modulator to help peri- and postmenopausal women maintain brain metabolism and thinking skills without increasing risk to breast tissue.

  NIH research University of Arizona · Tucson, United States · NIH-11300208

• Hormones, sleep, and memory across midlife and menopause

  A study at UC Irvine will explore how sex hormones and sleep affect memory in adults around midlife and during menopause.

  NIH research University of California-Irvine · Irvine, United States · NIH-11297359

• How heart muscle stiffness changes with age and menopause

  This project uses a painless, free-breathing MRI technique to measure heart muscle stiffness in adults, with special focus on changes that happen around menopause in women.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11261759

• MenoBrain: How Menopause Affects Brain Health

  This project follows midlife women during the perimenopause to see how hormone shifts, menopausal symptoms, sleep, and cardiovascular changes relate to memory and brain health over five years.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11251926

• Risk factors for psychosis during the menopause transition

  This project looks for medical, reproductive, psychiatric, and family-history signs that might predict new psychosis in women going through the menopause transition.

  NIH research Yale University · New Haven, United States · NIH-11238936

• Targeting Insomnia to Prevent Depression in Menopause

  A large study will test whether treating sleep problems with a digital cognitive-behavioral therapy program can help prevent depression in women going through menopause.

  NIH research Sri International · Menlo Park, United States · NIH-11219445

• Impact of menopause on blood pressure during exercise

  This study looks at how menopause affects blood pressure and leg blood flow during exercise in healthy women after menopause.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11203451

• A new treatment for vaginal issues related to menopause

  This study is testing a new treatment using a special gel to help relieve dryness and discomfort for women going through menopause, aiming to make them feel more comfortable and improve their vaginal health.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11187044

• How regular cannabis vaping affects mood, thinking, and metabolism after menopause

  Researchers expose menopause-model mice to regular cannabis vapor to learn how it may change mood, memory, and metabolism relevant to people after menopause.

  NIH research Washington State University · Pullman, United States · NIH-11159857

• Menopause-related DNA damage and gene-activity changes in Alzheimer's

  This project explores whether DNA damage and shifts in gene activity during menopause help explain why more women develop Alzheimer's disease.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11118919

• Understanding Brain Changes in Aging and Menopause Related to Alzheimer's

  This project looks at brain changes in aging and during menopause in a monkey model to better understand how Alzheimer's disease starts in people.

  NIH research Duke University · Durham, United States · NIH-11088744

Related topics

Quick answers

How many Menopause clinical trials are recruiting right now?

67, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (29 trials), Turkey (Türkiye) (5 trials), Spain (5 trials), Brazil (4 trials), United Kingdom (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Phase 1: 4, Phase 2/3: 3, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →