Understanding how menopause affects body temperature regulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of menopause on thermoregulation in women aged 42-64. It compares the responses to heat stress between premenopausal women, who will temporarily experience low estrogen levels through a GnRH antagonist, and postmenopausal women, who will receive a transdermal estradiol patch to elevate estrogen levels. Participants will undergo a series of heating experiments to assess their physiological responses under different hormonal conditions. The goal is to clarify how estrogen levels influence heat stress responses in the context of aging.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women ages 42-64

Exclusion Criteria:

* Chron's disease, diverticulitis, or similar gastrointestinal disease
* Abnormal resting exercise electrocardiogram (ECG)
* Tobacco use
* High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor
* Assessment
* Using hormone therapy
* Using hormonal contraceptives

Where it's running

• Noll Laboratory
  University Park, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: W. Larry Kenney, Ph.D. — The Pennsylvania State University
• Study coordinator: W. Larry Kenney, Ph.D.
• Email: w7k@psu.edu
• Phone: 814-863-1672

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Sex hormones, menopause, and exercise in aging women

  This study tests how hormonal status and resistance training affect age-related muscle and nerve function in postmenopausal women.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07848438

• Beta3-adrenergic Receptors and Vascular Function in Aging Women

  This trial tests whether activating beta3-adrenergic receptors can improve blood vessel function in aging women undergoing menopause.

  Recruiting Early Phase 1 University of Missouri-Columbia · Columbia, Missouri · NCT07674680

• Examining how aging and menopause affect blood vessel responses to low oxygen levels

  This study is testing how aging and menopause affect blood vessel responses to low oxygen levels in women by trying different medications to see how they help.

  Recruiting Early Phase 1 University of Missouri-Columbia · Columbia, Missouri · NCT06417177

• Effects of menopause on artery health and fat gain in women

  This study is testing how menopause and lower estrogen levels affect artery health and belly fat in women, and whether using an estrogen patch can help improve these issues.

  Recruiting Phase 4 University of Colorado, Denver · Aurora, Colorado · NCT06264882

• Effects of menopause and aging on weight gain and fat distribution

  This study is testing how menopause affects weight gain and belly fat in women by looking at hormones and seeing if adjusting these hormones can help reduce fat.

  Recruiting Phase 4 University of Colorado, Denver · Aurora, Colorado · NCT04043520

• Aquatic power training dosing strategies and creatine in older adults

  This trial tests whether different aquatic power training dosing methods and creatine supplementation help improve function in community-dwelling adults aged 60 and older.

  Recruiting University of Valencia · Valencia, Valencia · NCT07914270

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.