Vaginal DHEA vs Vaginal Estrogen for Menopause Symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this study, peri- or post-menopausal women with genitourinary symptoms are randomized to receive either vaginal DHEA or 0.01% estradiol vaginal cream for a defined treatment period. Participants complete questionnaires on symptoms and sexual health, and undergo simple vaginal assessments at baseline and study end. The goal is to compare effects on vaginal tissue health, sexual function, and urinary symptoms to inform treatment choices for menopausal care. The study is conducted at Banner University Medical Center Phoenix with University of Arizona as the lead sponsor. Randomization aims to minimize bias and provide fair comparisons between the two therapies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Peri- or post-menopausal status
* Presence of any genitourinary or vaginal symptom (e.g., dryness, itching, discomfort, dyspareunia)
* Willingness and ability to use vaginal therapy
* Ability to provide informed consent
* English speaker
* Ages 40-90

Exclusion Criteria:

* Use of systemic hormone therapy within the last 6 months
* Gynecologic malignancy
* Known allergy to study medications
* Active vaginal infection at enrollment
* Prior pelvic radiation

Where it's running

• Banner University Medical Center Phoenix
  Phoenix, Arizona, United States Recruiting

Study contacts

• Principal investigator: Molloy Shaida — University of Arizona
• Study coordinator: Iridian (Iris) Jaramillo, M.S.
• Email: iyjaramillo@arizona.edu
• Phone: 602-827-2078

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.