Investigating how menopause affects blood cell function and cardiovascular risk
Official title: Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity
Run by Heinrich-Heine University, Duesseldorf · NCT05985447 · Data updated 2026-11-12
This study is testing how menopause affects blood cells and heart health in both men and women to see if hormone changes increase cardiovascular risks, especially looking at the role of hormone replacement therapy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 180 (estimated) |
| Sponsor | Heinrich-Heine University, Duesseldorf Academic / other |
| Locations | 1 site (Düsseldorf) |
| Status | Recruiting |
| Started | March 7, 2022 |
| Main results expected | December 2025 |
| Study ends | December 2026 |
| Registry record updated | August 14, 2023 |
| Trial ID | NCT05985447 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals over 18 years old, both male and female, currently receiving treatment in the relevant departments.
✕Probably not a fit
Patients under 18 years old or those with coagulation disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the impact of menopause on leukocyte distribution, monocyte function, and platelet reactivity in both men and women. It focuses on understanding how hormonal changes during menopause influence cardiovascular risk profiles and outcomes, particularly in relation to the protective effects of estrogen. Blood samples will be collected from participants to analyze the differences in blood cell behavior and hormone levels, with a specific emphasis on the effects of hormone replacement therapy. The study seeks to clarify the mechanisms behind the increased cardiovascular risks observed in women post-menopause.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular risks in menopausal women.
How similar studies have gone: While there is existing literature on hormonal influences on cardiovascular health, this specific investigation into menopause-related changes is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Male, female, diverse patients with current treatment in the Department of Cardiology, Pneumology and Angiology. * Persons who are able to understand and follow the instructions of the study staff * Written informed consent Exclusion Criteria: * Age \< 18 years * Lack of written consent to participate in the study * coagulation disorders
Where it's running
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University-Hospital Düsseldorf Division of Cardiology, Pulmonary Disease and Vascular Medicine
Düsseldorf, Germany Recruiting
Study contacts
- Study coordinator: Lisa Dannenberg, MD
- Email: lisa.dannenberg@med.uni-duesseldorf.de
- Phone: +492118105315
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.