Investigating how menopause affects blood cell function and cardiovascular risk
Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity
This study is testing how menopause affects blood cells and heart health in both men and women to see if hormone changes increase cardiovascular risks, especially looking at the role of hormone replacement therapy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 180 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Heinrich-Heine University, Duesseldorf Academic / other |
| Locations | 1 site (Düsseldorf) |
| Trial ID | NCT05985447 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the impact of menopause on leukocyte distribution, monocyte function, and platelet reactivity in both men and women. It focuses on understanding how hormonal changes during menopause influence cardiovascular risk profiles and outcomes, particularly in relation to the protective effects of estrogen. Blood samples will be collected from participants to analyze the differences in blood cell behavior and hormone levels, with a specific emphasis on the effects of hormone replacement therapy. The study seeks to clarify the mechanisms behind the increased cardiovascular risks observed in women post-menopause.
Who should consider this trial
Good fit: Ideal candidates include individuals over 18 years old, both male and female, currently receiving treatment in the relevant departments.
Not a fit: Patients under 18 years old or those with coagulation disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular risks in menopausal women.
How similar studies have performed: While there is existing literature on hormonal influences on cardiovascular health, this specific investigation into menopause-related changes is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Male, female, diverse patients with current treatment in the Department of Cardiology, Pneumology and Angiology. * Persons who are able to understand and follow the instructions of the study staff * Written informed consent Exclusion Criteria: * Age \< 18 years * Lack of written consent to participate in the study * coagulation disorders
Where this trial is running
Düsseldorf
- University-Hospital Düsseldorf Division of Cardiology, Pulmonary Disease and Vascular Medicine — Düsseldorf, Germany (Recruiting)
Study contacts
- Study coordinator: Lisa Dannenberg, MD
- Email: lisa.dannenberg@med.uni-duesseldorf.de
- Phone: +492118105315
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.