Condition

Perimenopause clinical trials and research

• 20Clinical trials
• 17NIH research projects
• 2New in 30 days
• 12Countries

Newest Perimenopause clinical trials

All recruiting trials (20)

• Understanding immune clues to depression in perimenopause

  This study tests whether immune and epigenetic changes during perimenopause help explain why some women develop depression.

  Recruiting at 3 sites Van Andel Research Institute · Grand Rapids, Michigan and 3 other locations · NCT07910552

• Hop extract vs soy isoflavone for menopausal symptoms

  This study tests whether a full-spectrum hop extract helps reduce menopausal mood symptoms better than soy isoflavones in peri- and postmenopausal women.

  Recruiting Menoclinica by Palacios · Madrid, Madrid · NCT07904390

• Plant extract supplement for menopausal symptoms in women around menopause

  A plant-extract dietary supplement is being tested to see if it helps hot flashes and related symptoms in women aged 42–60 who are nearing or just past menopause, compared with a placebo.

  Recruiting University of Alicante · Elche, Alicante · NCT07863973

• Lifestyle changes to ease menopausal symptoms, sleep problems, and anxiety

  Researchers are testing whether a structured lifestyle education program helps perimenopausal and postmenopausal women see fewer menopausal symptoms, better sleep, and less anxiety compared to usual care.

  Recruiting Konya Beyhekim Training and Research Hospital · Konya, Konya · NCT07860645

• CARAMEL: Personalizing Heart Risk in Women 40–60

  This observational study tests a personalized cardiovascular risk-stratification approach for women aged 40–60 using multi-source data and a digital self-management tool.

  Recruiting at 3 sites Biogipuzkoa Health Research Institute · Bogotá and 5 other locations · NCT07695376

• Samphire Guided Care for Wellbeing at Work

  This study tests a 12-week digital program with at-home neuromodulation to see if it helps women with menstrual or perimenopausal symptoms feel better at work and in daily life.

  Recruiting Samphire Group, Inc. · San Francisco, California · NCT07679074

• Novel functional snack and perimenopause: does a fibre- and phytochemical-rich bite help symptoms?

  A daily snack enriched with phytochemicals and fiber is being tested to see if it can reduce perimenopausal symptoms and improve well-being in women aged 40–55 who are not using hormone therapy.

  Recruiting King's College London · London, London · NCT07599930

• Probiotic Intake to See If It Helps Perimenopausal Women Think and Feel Better

  We’re testing whether a multi-strain probiotic can improve emotional processing and cognitive function in perimenopausal women who have mood or cognitive concerns.

  Recruiting University of Oxford · Oxford, England · NCT07590999

• Intermittent fasting for mental health during perimenopause

  This trial will see if a 16/8 intermittent fasting plan helps improve mental health for women aged 45–55 who are in perimenopause.

  Recruiting American University of Beirut Medical Center · Beirut · NCT07481513

• Low-level laser acupuncture to improve body shape and composition in overweight menopausal women

  This trial will test whether adding low-level multi-acupoint laser acupuncture to WHO-recommended diet and exercise helps overweight or obese menopausal women lose weight and improve body composition.

  Recruiting Chang Gung Memorial Hospital · Keelung, Taiwan · NCT07472881

• Air program for perimenopause symptoms

  A 24-week remote program called AIR is tested to see if it helps perimenopausal symptoms more than waiting list care.

  Recruiting Chronic Conditions Research Fund · Decorah, Iowa · NCT07427459

• Hemp-derived cannabinoids for menopause and perimenopause symptom relief

  This will try hemp-derived cannabinoids versus placebo to see if they reduce physical and psychological symptoms in women aged 40–60 going through perimenopause or menopause.

  Recruiting Phase 2 Washington State University · Pullman, Washington · NCT07393672

• 16:8 time-restricted eating with a low glycaemic-index Mediterranean diet for perimenopausal and menopausal women

  This trial will test whether a 16:8 time-restricted eating schedule combined with a low glycaemic-index Mediterranean diet can improve thinking, metabolic health, and biological ageing in women aged 45–75 in late perimenopause or menopause with BMI ≥23.

  Recruiting University of Nicosia · Zagreb and 1 other locations · NCT07378787

• Resistance exercise to improve thinking during perimenopause

  This program will test whether twice-weekly progressive resistance training for six months helps memory and thinking in physically inactive perimenopausal biological females aged 40–55 who have noticed cognitive changes.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07272174

• Functional exercise plus a natural supplement for perimenopausal women's health

  This trial will test whether a natural nutritional supplement combined with supervised functional exercise can help improve mood, sleep, menopausal symptoms, thinking, and physical function in perimenopausal women.

  Recruiting University of Valencia · Valencia, Valencia · NCT07251296

• Resistance training with a plant-based supplement for perimenopausal symptoms and muscle health

  This trial tests whether a plant-based supplement (sarmentosin + L-theanine), resistance training, or the combination can help perimenopausal women with mood, sleep, cognition, strength, and muscle mass.

  Recruiting Leeds Beckett University · Leeds, North Humberside · NCT07135232

• Wearable device to track perimenopausal and menopausal symptoms

  This project will test whether a wearable sensor can accurately detect hot flashes, night sweats, sleep problems, and anxiety-related signals in women aged 35–55 going through perimenopause by comparing device readings with daily reports in an app.

  Recruiting IdentifyHer Limited · London, Ontario · NCT07022925

• How twice-weekly weight training affects blood vessel health in perimenopause

  This trial will test whether lifting weights twice a week for 16 weeks helps improve blood vessel health, mood, sleep, and menopause symptoms in women experiencing perimenopause.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07022340

• Online therapy for anxiety in women going through menopause

  This study is testing an online therapy program to see if it can help women going through menopause feel less anxious.

  Recruiting at 2 sites Queen's University · Kingston, Ontario and 1 other locations · NCT06865066

• Effects of melatonin on heart health during menopause

  This study is testing if taking melatonin for 12 weeks can help improve heart health in women aged 40-55 who are going through perimenopause and have high blood pressure.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06826755

NIH-funded research (17)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Computationally defining perimenopause in big health records for midlife women

  A patient-centered project to create a reliable way to identify the perimenopause period in electronic health records, so clinicians can better understand and prevent related health risks.

  NIH research University of Rochester · Rochester, United States · NIH-11435538

• Timing of Menopausal Hormone Therapy to Protect Brain Health in Perimenopause

  A research program uses AI and real-world data to understand how menopausal hormone therapy affects brain health and Alzheimer’s risk in women around menopause.

  NIH research University of Arizona · Tucson, United States · NIH-11423210

• Timing of Menopausal Hormone Therapy and Brain Biomarkers in Women at Risk for Alzheimer's Disease

  This study explores whether starting menopausal hormone therapy during a key window can influence brain markers and risk of Alzheimer's in women who are perimenopausal or postmenopausal.

  NIH research University of Arizona · Tucson, United States · NIH-11423209

• Timing of menopausal hormone therapy and brain aging in Alzheimer's risk

  A research program is exploring how menopause-era hormone therapy affects brain aging and biomarkers related to Alzheimer's risk in women.

  NIH research University of Arizona · Tucson, United States · NIH-11423208

• Timing of Hormone Therapy and Brain Health in Perimenopause

  A study looking at how the timing and type of menopausal hormone therapy affect brain metabolism related to Alzheimer’s risk in women going through perimenopause.

  NIH research University of Arizona · Tucson, United States · NIH-11423207

• Timing of Menopausal Hormone Therapy and Brain Aging in Women at Risk for Alzheimer's Disease

  This NIH grant explores how the timing of hormone therapy during perimenopause affects brain aging and Alzheimer's risk in women.

  NIH research University of Arizona · Tucson, United States · NIH-11423206

• Perimenopause and Brain Aging: Reducing Alzheimer’s Risk in Women

  A large research program aims to understand why women have different risks of Alzheimer’s disease around menopause and how hormone therapy can be optimized to protect brain health.

  NIH research University of Arizona · Tucson, United States · NIH-11423201

• Understanding how menopause may affect brain signals linked to psychosis in a rodent model

  A study in a rodent model of perimenopause looks at how brain circuits linked to psychosis might change and how to possibly prevent those changes.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11375507

• Immune changes linked to depression during perimenopause

  This project looks at how hormone-related immune changes may cause depression in women going through perimenopause.

  NIH research Van Andel Research Institute · Grand Rapids, United States · NIH-11250128

• How phthalates and metals during pregnancy and perimenopause affect bone health and body composition later in life

  This research looks at how common chemicals like phthalates and metals, encountered during pregnancy and around menopause, might impact women's bone strength and body fat later in life.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11138598

• Perimenopause, brain aging, and Alzheimer's risk

  This program explores how hormonal and metabolic changes during perimenopause affect brain aging and Alzheimer's risk for middle-aged women, with special attention to APOE-e4.

  NIH research University of Arizona · Tucson, United States · NIH-11129666

• Investigating how exposure to certain chemicals during pregnancy and perimenopause affects bone health and body composition.

  This study looks at how certain chemicals found in everyday products might affect bone health and body changes in women who are pregnant or going through menopause, helping us understand the risks these exposures could pose during important times in life.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11129019

• Understanding Brain Changes in Perimenopause and Psychosis

  This project explores how brain changes during perimenopause might lead to psychosis and seeks new ways to help women experiencing these symptoms.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11106007

• Understanding how hormonal changes during perimenopause affect depression.

  This study is looking at how hormonal changes during perimenopause might affect the immune system and contribute to depression in women, with the goal of finding new ways to help those who are feeling down during this time.

  NIH research Van Andel Research Institute · Grand Rapids, United States · NIH-11072385

• Investigating dopamine system changes during perimenopause and their link to psychosis.

  This study is looking at how changes in a brain chemical called dopamine during perimenopause might raise the chances of developing mental health issues, and it's using a rodent model to understand how certain brain areas affect this process, with the hope of finding new treatments to help women during this time.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-10936510

• Investigating how menopause and sleep apnea affect brain health in middle-aged women with diabetes

  This study is looking at how menopause and sleep apnea affect brain health in middle-aged women with Type 2 Diabetes, especially those from diverse backgrounds, to better understand their unique health challenges and improve their well-being.

  NIH research University of Houston · Houston, United States · NIH-10931635

• Investigating how exposure to certain chemicals during pregnancy and menopause affects bone health and body composition.

  This study is looking at how everyday chemicals like phthalates and heavy metals might affect bone health and body changes in women who are pregnant or going through menopause, and it’s for women who want to learn more about the potential risks of these substances during important times in their lives.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10899764

Related topics

Quick answers

How many Perimenopause clinical trials are recruiting right now?

20, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (6 trials), Spain (4 trials), United Kingdom (3 trials), Canada (3 trials), Croatia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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