Examining how aging and menopause affect blood vessel responses to low oxygen levels

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of aging and menopause on how blood vessels respond to hypoxia in women. It focuses on the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women. Participants will receive either a placebo, propranolol, or gemtesa to assess their vascular responses. The study aims to enhance understanding of vascular health in relation to menopause and aging.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female assigned at birth
* Pre, peri- or post-menopausal
* Healthy weight (BMI ≥18 and ≤30 kg/m2)

Exclusion Criteria:

* Male (assigned at birth)
* Pregnancy, breastfeeding
* Use of hormone replacement therapies
* Hysterectomy
* Body mass index \>30 kg/m2
* Diagnosed sleep apnea
* Current smoking/Nicotine/Drug use
* Nerve/neurologic disease
* Cardiovascular, hepatic, renal, respiratory disease
* Blood pressure ≥140/90 mmHg
* Diabetes, Polycystic ovarian syndrome
* Communication barriers
* Prescription medications
* Malignant cancer

Where it's running

• University of Missouri-Columbia
  Columbia, Missouri, United States Recruiting

Study contacts

• Study coordinator: Jacqueline Limberg
• Email: limberglab@missouri.edu
• Phone: 573-882-2544

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Short mild low-oxygen sessions to support brain blood-vessel health in older adults

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.