Examining how aging and menopause affect blood vessel responses to low oxygen levels
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
This study is testing how aging and menopause affect blood vessel responses to low oxygen levels in women by trying different medications to see how they help.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | Female |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 1 site (Columbia, Missouri) |
| Trial ID | NCT06417177 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of aging and menopause on how blood vessels respond to hypoxia in women. It focuses on the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women. Participants will receive either a placebo, propranolol, or gemtesa to assess their vascular responses. The study aims to enhance understanding of vascular health in relation to menopause and aging.
Who should consider this trial
Good fit: Ideal candidates are women assigned at birth who are premenopausal, perimenopausal, or postmenopausal with a healthy weight.
Not a fit: Patients who are male, pregnant, or have certain health conditions such as cardiovascular disease or diabetes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatments for vascular issues related to aging and menopause.
How similar studies have performed: Other studies have explored vascular responses in aging populations, but this specific focus on menopause and hypoxia is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female assigned at birth * Pre, peri- or post-menopausal * Healthy weight (BMI ≥18 and ≤30 kg/m2) Exclusion Criteria: * Male (assigned at birth) * Pregnancy, breastfeeding * Use of hormone replacement therapies * Hysterectomy * Body mass index \>30 kg/m2 * Diagnosed sleep apnea * Current smoking/Nicotine/Drug use * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications * Malignant cancer
Where this trial is running
Columbia, Missouri
- University of Missouri-Columbia — Columbia, Missouri, United States (Recruiting)
Study contacts
- Study coordinator: Jacqueline Limberg
- Email: limberglab@missouri.edu
- Phone: 573-882-2544
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.