Condition

Acne clinical trials and research

• 12Clinical trials
• 18NIH research projects
• 1New in 30 days
• 11Countries

Newest Acne clinical trials

All recruiting trials (12)

• Adapalene/Clindamycin Gel in Vietnamese Acne Patients

  This study tests how safe and tolerable and how well Klenzit-C works when used in routine care by Vietnamese patients aged 12 and up with mild to moderate acne.

  Recruiting at 2 sites Phase 4 Ir Innovate Research Private Limited · Hanoi and 2 other locations · NCT07918001

• Skincare regimen for mild to moderate acne in people with sensitive skin

  A 4-week test will check if a skincare regimen helps with mild to moderate acne in adults with sensitive skin.

  Recruiting USMARI Research & Innovation Centre · Petaling Jaya, Selangor · NCT07749469

• Engineered Lactobacillus reuteri cream with zinc sulfate–tannic acid MPN coating for acne

  This trial will test whether a topical cream containing engineered Lactobacillus reuteri with a zinc sulfate–tannic acid coating can reduce inflammatory acne in adults aged 18–33.

  Recruiting Phase 2 Shenzhen People's Hospital · Shenzhen, Guangdong · NCT07366229

• Probiotic drink for skin inflammation during the menopausal transition

  This study will test whether a daily Lactobacillus casei Shirota probiotic drink can reduce inflammation and improve immune and skin health in women aged 40–60 going through the menopausal transition with inflammatory facial skin conditions.

  Recruiting King's College London · London, London · NCT07341087

• Acne mRNA vaccine for adults with mild facial acne

  This trial will test two injections of an acne mRNA vaccine versus placebo in adults 18–45 with mild facial acne to see if it's safe, triggers an immune response, and improves acne.

  Recruiting at 4 sites Phase 1/2 Sanofi · Encino, California and 3 other locations · NCT07013747

• Evaluating the safety and effects of TVB-3567 in healthy individuals and those with acne

  This study is testing a new drug called TVB-3567 to see how safe it is and how it works in healthy people and those with acne.

  Recruiting at 3 sites Phase 1 Sagimet Biosciences Inc. · Tempe, Arizona and 5 other locations · NCT06989840

• Treatment for various skin conditions using AVAVA technology

  This study is testing a new device called AVAVA to see if it can help improve skin problems like acne, scars, and wrinkles.

  Recruiting AVAVA, Inc. · Waltham, Massachusetts · NCT06868615

• Post-market follow-up of ChitoCare® Medical for scars, post-dermatological care, dermatitis, and acne

  This project will try ChitoCare® Medical gel and spray to see if they are safe and help heal scars, skin after dermatologic procedures, dermatitis, and acne in people who use them.

  Recruiting at 2 sites Primex ehf · Prague and 1 other locations · NCT06850389

• Comparing a cosmetic product for treating facial acne in young adults

  This study tests whether a new cosmetic product can help teenagers and young adults with acne when used alongside their regular acne treatment.

  Recruiting Pierre Fabre Dermo Cosmetique · São Paulo · NCT06716398

• Evaluating an mRNA vaccine for treating moderate to severe acne

  This study is testing a new mRNA vaccine to see if it can safely help adults aged 18 to 45 with moderate to severe acne.

  Recruiting at 94 sites Phase 1/2 Sanofi · Scottsdale, Arizona and 93 other locations · NCT06316297

• Collecting samples from people with skin conditions and healthy volunteers

  This study is collecting samples from people with different skin conditions and healthy volunteers to see how their biology differs and learn more about these conditions.

  Recruiting Innovaderm Research Inc. · Montreal, Quebec · NCT05994976

• Cohort of patients treated for acne at Nantes University Hospital

  This study is looking at first-time acne patients at Nantes University Hospital to see how different factors affect their acne and their quality of life.

  Recruiting Nantes University Hospital · Nantes · NCT03465150

NIH-funded research (18)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Acne: how skin oils, bacteria, and the immune system interact

  A UC system grant is exploring how acne develops by looking at skin oils, skin bacteria, and the body’s immune response to help find new ways to prevent or treat acne.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11393075

• Acne: how skin bacteria, fats, and immunity drive lesions

  A large NIH-funded effort at UCLA/UCSD is studying how skin bacteria, fat metabolism, and the immune system interact to cause acne, with plans to translate findings into better treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11393068

• Spironolactone vs doxycycline for acne in women

  A multi-center trial compares spironolactone and doxycycline to treat acne in adult women to find which works better with fewer side effects.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11387827

• Novel endolysins to target Cutibacterium acnes for acne treatment

  A small research grant is developing a highly specific enzyme therapy to kill the acne-causing bacteria without disturbing good skin or gut bacteria.

  NIH research Topaz Biosciences, INC. · Emeryville, United States · NIH-11381883

• Th17 extracellular traps and skin bacteria in acne health

  A study in people with acne aims to understand how specific skin bacteria and immune cells interact to fight acne-causing germs and how this could lead to better treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11374876

• New bacteria-targeting enzymes to fight acne

  Developing species-specific enzymes to remove the acne-causing bacterium Cutibacterium acnes for people with acne.

  NIH research Topaz Biosciences, INC. · Emeryville, United States · NIH-11183989

• How skin oils, bacteria, and the immune system cause acne

  Researchers are exploring how skin oils, the bacteria on your skin, and immune cells interact in people with acne to find better treatment targets.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11178651

• How skin oils, bacteria, and the immune system cause acne

  This project looks at how skin oils, microbes, and immune cells cause acne to help people with inflammatory acne.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11178636

• Spironolactone versus doxycycline for acne in women

  This trial compares two commonly used oral acne medicines—spironolactone and doxycycline—to find which helps adult women get clearer skin with fewer side effects.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11169688

• Understanding the Immune System's Role in Acne

  This research explores how our body's immune cells fight the bacteria that cause acne, hoping to find new ways to treat it.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11123418

• Understanding how immune responses affect acne treatment

  This study is looking at how certain immune cells and bacteria related to acne work together, with the goal of finding new ways to help treat acne and improve skin health for people who struggle with it.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11122440

• Investigating how the microbiome, fat metabolism, and immune response contribute to acne

  This study is looking at how the bacteria on our skin, the way our body processes fats, and our immune system all work together to cause acne, and it's for anyone who wants to understand more about what triggers their breakouts.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10913496

• Understanding how bacteria, fat metabolism, and the immune system contribute to acne

  This study is looking at how the bacteria on your skin, the fats in your body, and your immune system all work together to cause acne, using skin samples to find out which cells and bacteria are involved, so we can better understand and treat this common skin condition.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10913491

• Understanding acne in transgender individuals

  This study is looking at how acne affects transgender people, especially those on hormone therapy, to learn more about how common and serious acne is for them and how it impacts their mental health and daily life.

  NIH research Emory University · Atlanta, United States · NIH-10898586

• Understanding how immune responses affect acne

  This study is looking at how certain immune cells in your skin interact with the bacteria that causes acne, to find out how they can help clear up breakouts or make them worse, with the hope of discovering new ways to treat acne more effectively.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10880415

• New oral treatment for severe acne using selective CYP26 inhibitors.

  This study is testing a new pill that aims to help people with severe acne by blocking certain enzymes that break down a skin-friendly vitamin, hoping to improve acne without the usual side effects of current treatments.

  NIH research Dermaxon, LLC · Missoula, United States · NIH-10822482

• Comparing spironolactone and doxycycline for treating acne in women

  This study is looking at how well two medications, spironolactone and doxycycline, work for treating moderate to severe acne in women, and by joining, you could help find out which one might be better for your skin!

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10699996

• Understanding how specific enzymes from bacteria affect acne

  This study is looking at how different types of acne-causing bacteria can affect your skin, especially by examining certain enzymes that can either make acne worse or help keep your skin healthy, with the hope of finding new ways to prevent or treat acne.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10653696

Related topics

Quick answers

How many Acne clinical trials are recruiting right now?

12, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (4 trials), Australia (2 trials), Canada (2 trials), France (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Phase 1: 1, Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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