Beta3-adrenergic Receptors and Vascular Function in Aging Women
Official title: Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
Run by University of Missouri-Columbia · NCT07674680 · Data updated 2026-11-12
This trial tests whether activating beta3-adrenergic receptors can improve blood vessel function in aging women undergoing menopause.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 70 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 1 site (Columbia, Missouri) |
| Status | Recruiting |
| Started | July 31, 2026 |
| Main results expected | May 2028 |
| Study ends | May 2029 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT07674680 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy women assigned female at birth, 18–70 years old, with BMI <18 or ≥30 kg/m2, not pregnant or breastfeeding, and without specified exclusions.
✕Probably not a fit
Individuals with cardiovascular, metabolic, or hormonal conditions listed in exclusion criteria, or those with active smoking, pregnancy, or recent hormone therapies, may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This early-phase study explores if vascular beta3-adrenergic receptors are present and functional in aging women and whether targeting them can reduce sympathetic vasoconstriction and improve vascular function. Participants are healthy, post-menarcheal women aged 18 to 70, with BMI in the underweight or obese range, who receive either a placebo or Gemtesa. The study uses a randomized, controlled design typical of first-in-human assessments to evaluate safety, tolerability, and preliminary signals of vascular response. Primary outcomes focus on vascular function markers and receptor activity, while safety monitoring screens for cardiovascular and metabolic risks. Conducted at a single site (University of Missouri-Columbia), the trial aims to inform whether beta3-adrenergic modulation could be a therapeutic approach in aging female vascular health.
Why it matters
Potential benefit: If successful, participants may experience improved vascular function and reduced sympathetic vasoconstriction related to aging and menopause.
How similar studies have gone: Previous research in beta3-adrenergic pathways has shown potential in vascular modulation, but this early-phase study represents a relatively novel application in aging women.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy women, * Assigned female at birth, * 18-70 years of age, * Body mass index \<18 or ≥30 kg/m2, Exclusion Criteria: * Assigned male at birth, * Pregnancy, * Breastfeeding, * History of hormone replacement therapy, chemical menopause, or oophor-ectomy * Polycystic ovarian syndrome or Primary ovarian insufficiency, * Current smoking/Nicotine use, * Blood pressure ≥140/90 mmHg, * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy, * Nerve/neurologic disease, * Cardiovascular, hepatic, renal, respiratory disease, * Hypersensitivity to nitroglycerin, * Diabetes, * Communication barriers,
Where it's running
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University of Missouri
Columbia, Missouri, United States Recruiting
Study contacts
- Study coordinator: Jacqueline Limberg Associate Professor
- Email: limberglab@missouri.edu
- Phone: 1-573-882-2544
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.