Using PRP injections to restore ovarian function in menopausal women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of autologous platelet-rich plasma (PRP) intra ovarian infusion in reactivating ovarian functionality and promoting folliculogenesis in menopausal women. The study is a triple-blind randomized controlled trial that aims to evaluate how PRP, enriched with growth factors, can stimulate tissue proliferation and improve hormonal profiles. Participants will receive either PRP or a placebo infusion, and their ovarian function will be monitored over time to assess the treatment's impact. The trial seeks to provide insights into the potential of PRP for ovarian rejuvenation, a concept that has not been fully explored in the context of menopause.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 45-55 years old
* Amenorrhea for at least 12 months
* Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.
* Willing to comply with study requirements

Exclusion Criteria:

* Any pathological disorder related to reproductive system anatomy
* Previous POI diagnosis
* Abnormal karyotype
* Endometriosis
* Adenomyosis
* Fibroids and adhesions
* Infections in reproductive system
* Current or previous diagnosis of reproductive system cancer
* History of familiar cancer in reproductive system
* Severe male factor infertility
* Prior referral for PGT
* Ovarian inaccessibility
* Endocrinological disorders (Hypothalamus-Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
* BMI\>30 kg/m2 or BMI\<18.5 kg/m2
* Systematic autoimmune disorders

Where it's running

• Genesis AC
  Athens, Greece Recruiting

Study contacts

• Principal investigator: Agni Pantou, MD — Centre of Human Reproduction, Genesis Athens Clinic
• Study coordinator: Mara Simopoulou, PhD
• Email: marasimopoulou@hotmail.com
• Phone: +306979234100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.