Menopause, hormones, and blood pressure in women
Official title: Influence of menopause and sex hormone deficiency on autonomic and vascular determinants of blood pressure
Funded at University of Minnesota · NIH-11341862 · Data updated 2026-11-12
This grant explores how menopause and hormone changes affect blood pressure and the body's heart-blood vessel system in women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 17, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $791,971 |
| NIH project number | 1R01AG100223-01 |
| Project ID | NIH-11341862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women who are approaching or undergoing the menopausal transition, and who may be candidates for ovarian suppression or hormone-related studies.
✕Less likely to help
Some participants may not experience changes in autonomic or vascular function during the study.
What this research studies
This project will study how menopause and hormone tweaks influence autonomic control of blood pressure and how blood vessels respond in midlife women. Researchers will look at sympathetic activity, baroreflex function, vascular conductance, and endothelial function to understand sex-specific factors in blood pressure regulation. They will also examine what happens when ovarian function is suppressed with a GnRH antagonist and whether estradiol levels explain any observed changes. The work is based at the University of Minnesota with a team led by Dr. Manda Keller-Ross and collaborators to advance neighborhood-specific insights for women’s cardiovascular health.
Why it matters
Potential benefit: If successful, findings could lead to more personalized strategies for preventing hypertension and cardiovascular disease in menopausal women.
How similar studies have gone: Previous work has shown aging and sex hormones influence blood pressure, but this study aims to clarify mechanisms in menopausal transition.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Keller-Ross, Manda Linea — University of Minnesota
- Study coordinator: Keller-Ross, Manda Linea
Related research
Other NIH-funded projects on the same topics.
-
Impact of menopause on blood pressure during exercise
This study looks at how menopause affects blood pressure and leg blood flow during exercise in healthy women after menopause.
-
Actions to Decrease Disparities in Blood Pressure Control for Blacks
Aiming to help Black patients manage high blood pressure by using nurses, community health workers, and home monitoring in real-world clinics.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
-
Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
-
Non-invasive, continuous blood pressure monitoring for prenatal maternal health
A wearable device from PyrAmes uses comfortable, non-invasive sensors and smart software to constantly monitor a pregnant person’s blood pressure and heart health so doctors can protect both mom and baby.
-
Smartphone app helps pregnant women in Ghana monitor blood pressure at home
A smartphone app is being customized for pregnant women in Ghana to support home blood pressure monitoring and improve safety during pregnancy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.