Breast and Blood Vessel Effects of Menopause Hormone Therapy in Postmenopausal Women
Official title: Prospective Evaluation of the Effects of Menopausal Hormone Therapy on Breast Imaging Findings and Carotid Intima-Media Thickness in Postmenopausal Women
Run by Sanliurfa Mehmet Akif Inan Education and Research Hospital · NCT07810959 · Data updated 2026-11-12
This observational study will see if systemic menopause hormone therapy changes breast density and carotid artery thickness over 12 months in postmenopausal women.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 45 Years to 60 Years |
| Sex | Women only |
| Enrollment | 120 (estimated) |
| Sponsor | Sanliurfa Mehmet Akif Inan Education and Research Hospital Academic / other |
| Locations | 1 site (Bursa) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | May 31, 2027 |
| Study ends | May 31, 2027 |
| Registry record updated | September 9, 2026 |
| Trial ID | NCT07810959 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are postmenopausal women aged 45-60 with menopausal symptoms who are considering or currently receiving systemic menopausal hormone therapy and have recent breast imaging.
✕Probably not a fit
Some participants may not experience changes in breast density or carotid measurements despite therapy.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-center, observational cohort study comparing postmenopausal women who receive systemic menopausal hormone therapy with those who do not. Participants will be followed for 12 months with baseline, 3-, 6-, and 12-month assessments of breast imaging (ultrasound and tomosynthesis), breast density, menopausal symptoms, endometrial findings, cardiometabolic parameters, and carotid intima-media thickness. The primary goal is to see how breast density changes over time with therapy, while monitoring safety-related endpoints. Enrollment targets 120 women aged 45-60, with data collected through standard clinical practice. Analysis will consider treatment type, dose, duration, and patient characteristics to interpret imaging and vascular findings.
Why it matters
Potential benefit: If successful, the study could help clarify how menopausal hormone therapy influences breast tissue and cardiovascular risk markers.
How similar studies have gone: Previous studies on MHT have shown mixed effects on breast tissue and cardiovascular risk, making this observational data valuable for context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged 45-60 years * Postmenopausal status, defined as at least 12 months of amenorrhea since the final menstrual period * Presentation with menopausal symptoms * Baseline breast ultrasonography available * Mammographic imaging performed within the previous 12 months * Ability to comply with the 12-month follow-up protocol * Provision of written informed consent Exclusion Criteria: * Perimenopausal status * Use of any menopausal hormone therapy within the previous 6 months * History of breast cancer or active breast cancer * Suspicious breast lesion at baseline imaging (BI-RADS category 4 or higher) * Unexplained uterine bleeding * Absolute contraindication to menopausal hormone therapy, including active thromboembolic disease, previous myocardial infarction, or active liver disease
Where it's running
-
Acıbadem Bursa Hospital
Bursa, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Nefise Nazlı Yenigül
- Phone: 5058254618
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Hop extract vs soy isoflavone for menopausal symptoms
This study tests whether a full-spectrum hop extract helps reduce menopausal mood symptoms better than soy isoflavones in peri- and postmenopausal women.
-
Resveratrol and Estrogen Receptors in Postmenopausal Women with CAD
This study tests whether taking resveratrol is safe and can change estrogen-related markers in postmenopausal women with coronary artery disease.
-
Ashoka Bark and Shatavari for Menopause
This 12-week study tests whether a daily Ashoka Bark and Shatavari supplement helps reduce menopausal symptoms in postmenopausal women compared with a placebo.
-
Lifestyle changes to ease menopausal symptoms, sleep problems, and anxiety
Researchers are testing whether a structured lifestyle education program helps perimenopausal and postmenopausal women see fewer menopausal symptoms, better sleep, and less anxiety compared to usual care.
-
Pain and period life: does menstrual cycle or menopause change pain during root canals?
This study will see if pain during a root canal varies with menstrual cycle phase or menopausal status in adult patients.
-
Sex hormones, menopause, and exercise in aging women
This study tests how hormonal status and resistance training affect age-related muscle and nerve function in postmenopausal women.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.