AGEWISE: Exploring how the gut microbiome and hormones change as women age

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

AGEWISE is an observational study in healthy women aged 40–64 living in Portugal. Researchers will collect stool and blood samples and have participants complete questionnaires about health, lifestyle, diet, and menopausal symptoms. The goal is to link gut microbiome data with hormone levels and inflammation markers to understand menopause-related ageing and identify potential biomarkers for personalized risk assessment. Findings may inform prevention strategies for age-related health issues in women. No intervention is involved; the study observes natural changes across the menopausal transition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female sex
* Aged 40 to 64 years
* Resident in mainland Portugal or the islands
* Able and willing to provide written informed consent
* Willing to provide stool and blood samples and complete three questionnaires

Exclusion Criteria:

* Age below 40 years or 65 years and older
* Inability to give informed consent
* Refusal to provide stool or blood samples or complete questionnaires
* Pregnancy
* Diagnosed gastrointestinal disorders (including inflammatory bowel disease, Crohn's disease, ulcerative colitis, irritable bowel syndrome, chronic diarrhoea of unknown cause, or recurrent Clostridioides difficile infection)
* Active oncological disease

Where it's running

• Gulbenkian Institute for Molecular Medicine, Lisbon
  Lisbon, Portugal Recruiting

Study contacts

• Study coordinator: Ana S Almeida, PhD
• Email: ana.almeida@gimm.pt
• Phone: +351 217999411

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.