Clinical trial Recruiting at 1 site Observational Ages 18 and up Women only

Pain and period life: does menstrual cycle or menopause change pain during root canals?

Official title: Effects of Menstrual Cycle Phases and Menopause on Pain Perception in Endodontic Therapy

Run by Nigde Omer Halisdemir University · NCT07850167 · Data updated 2026-11-12

This study will see if pain during a root canal varies with menstrual cycle phase or menopausal status in adult patients.

More Menopause trials

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment130 (estimated)
SponsorNigde Omer Halisdemir University
Academic / other
Locations1 site (Niğde)
StatusRecruiting
StartedMarch 10, 2026
Main results expectedMarch 2027
Study endsMarch 2027
Registry record updatedSeptember 30, 2026
Trial IDNCT07850167 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) scheduled for root canal treatment who can report menstrual cycle phase or menopausal status.

Probably not a fit

Patients experiencing pain unrelated to hormonal status or those not completing pain assessments may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll adults undergoing root canal treatment and collect information about their menstrual cycle phase or menopausal status. Pain will be measured at different points during the procedure and in follow-up visits, without any treatment based on cycle phase. The analysis will explore associations between cycle phase, menopausal status, and both intraoperative and post-treatment pain experiences. Participants provide self-reported information on reproductive status and pain scores to help clarify whether hormonal status influences dental pain perception.

Why it matters

Potential benefit: If associations are found, this could guide clinicians in anticipating pain experiences and improving patient comfort during endodontic care.

How similar studies have gone: Past research has explored hormonal influences on pain, with mixed results; this study adds observational data in dental pain.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Willing to participate in the study
* Aged 18 years or older
* Having at least one tooth requiring root canal treatment

Exclusion Criteria:

* Aged under 18 years
* No tooth requiring root canal treatment
* Male sex
* Diagnosis of endometriosis or polycystic ovary syndrome (PCOS)
* Use of oral contraceptives
* Receiving hormone therapy

Where it's running

  • Niğde Omer Halisdemir University
    Niğde, Turkey (Türkiye)
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.