Clinical trial Recruiting at 1 site Interventional Ages 40 to 60 Women only

Investigating hot flashes and their impact on women's vascular health

Official title: Hot Flashes and Neurovascular Function in Women

Run by Mayo Clinic · NCT05193968 · Data updated 2026-11-12

This study is testing how hot flashes might affect women's heart and blood vessel health, especially during menopause, to see if they increase the risk of high blood pressure and heart disease.

More Menopause trials

Quick facts

Study typeInterventional
Ages40 Years to 60 Years
SexWomen only
Enrollment120 (estimated)
SponsorMayo Clinic
Academic / other
Locations1 site (Rochester, Minnesota)
StatusRecruiting
StartedFebruary 24, 2022
Main results expectedDecember 2026
Study endsDecember 2026
Registry record updatedJune 12, 2026
Trial IDNCT05193968 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are non-smoking, non-obese women who have at least one ovary and are free from cardiovascular disease.

Probably not a fit

Patients with existing cardiovascular disease or those taking medications that influence cardiovascular function may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the relationship between hot flashes and neurovascular function in women, particularly focusing on how these symptoms may increase the risk of hypertension and cardiovascular disease. It involves the use of various sympathoexcitatory stressors and medications to assess neurovascular control mechanisms. By understanding these connections, the research aims to provide insights into the cardiovascular risks associated with menopause. The study is conducted at the Mayo Clinic in Rochester, Minnesota.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular risks in women experiencing hot flashes.

How similar studies have gone: Other studies have indicated a potential link between menopausal symptoms and cardiovascular health, suggesting that this approach may yield valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Non-smokers.
* Non-obese.
* Have at least one ovary.
* Free from cardiovascular disease.
* Not taking medications influencing cardiovascular function.

Exclusion Criteria:

\- None.

Where it's running

  • Mayo Clinic in Rochester
    Rochester, Minnesota, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.