Investigating hot flashes and their impact on women's vascular health
Official title: Hot Flashes and Neurovascular Function in Women
Run by Mayo Clinic · NCT05193968 · Data updated 2026-11-12
This study is testing how hot flashes might affect women's heart and blood vessel health, especially during menopause, to see if they increase the risk of high blood pressure and heart disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 60 Years |
| Sex | Women only |
| Enrollment | 120 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | February 24, 2022 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | June 12, 2026 |
| Trial ID | NCT05193968 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are non-smoking, non-obese women who have at least one ovary and are free from cardiovascular disease.
✕Probably not a fit
Patients with existing cardiovascular disease or those taking medications that influence cardiovascular function may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines the relationship between hot flashes and neurovascular function in women, particularly focusing on how these symptoms may increase the risk of hypertension and cardiovascular disease. It involves the use of various sympathoexcitatory stressors and medications to assess neurovascular control mechanisms. By understanding these connections, the research aims to provide insights into the cardiovascular risks associated with menopause. The study is conducted at the Mayo Clinic in Rochester, Minnesota.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular risks in women experiencing hot flashes.
How similar studies have gone: Other studies have indicated a potential link between menopausal symptoms and cardiovascular health, suggesting that this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Non-smokers. * Non-obese. * Have at least one ovary. * Free from cardiovascular disease. * Not taking medications influencing cardiovascular function. Exclusion Criteria: \- None.
Where it's running
-
Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Sarah Baker, PhD — Mayo Clinic
- Study coordinator: Pamela A Engrav
- Email: engrav.pamela@mayo.edu
- Phone: 507-255-6938
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study tests whether an 8-week daily herbal extract containing Shatavari can reduce menopausal symptoms in postmenopausal women, compared with a placebo.
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Fezolinetant to reduce hot flashes in men on androgen-deprivation therapy
This trial will test whether taking fezolinetant once daily for 4 weeks reduces how often and how severe hot flashes are in men with prostate cancer who are on androgen-deprivation therapy.
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Breathing muscle training to help midlife women with menopause symptoms
This study is testing if breathing exercises can help women aged 45-60 feel better during menopause by reducing hot flashes and improving sleep quality.
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Using Shatavari to treat menopausal symptoms in women
This study is testing if Shatavari can help women aged 45 to 65 feel better during menopause by reducing symptoms like hot flashes and mood swings.
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Virtual registry for menopause and perimenopause in Australia
This study is creating an online registry to collect information from Australian women about their experiences with menopause and perimenopause to help improve healthcare and support for them.
-
Examining the cardiovascular effects of hot flushes in postmenopausal women
This study tests how hot flushes affect heart and breathing responses in postmenopausal women to see if symptoms and body fat impact these effects.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.