Evaluating treatments for joint pain in menopausal women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the effectiveness of muscle strengthening exercises (MSE), estrogen therapy (ET), and a combination of both in alleviating arthralgia in women experiencing menopausal symptoms. Participants will be randomized into four groups: usual care, ET only, MSE only, and a combination of MSE and ET, with each intervention lasting 12 weeks. The study aims to assess feasibility, patient acceptability, and the practicality of outcome assessment tools. Participants will receive tailored exercise protocols and hormone therapy as needed, with assessments conducted at baseline and after 12 weeks.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA:

1. Patients with muscle stiffness and joint discomfort in various sites, including hands, knees, back, hips, and/or shoulders. Patients with pain in only one isolated joint would not be accepted.
2. Arthralgia symptoms with onset, or has become worse, over the perimenopausal or early postmenopausal period (within 5 years of the menopause).
3. Women should be at the menopause transition, less than or equal to 59 years old at the time of enrollment, or within 5 years of menopause whichever is earlier.

   .
4. Arthralgia for at least 3 months (pain lasting beyond normal injury healing period)
5. Community-dwelling and able to ambulate independently.

EXCLUSION CRITERIA:

1. History of thrombo-embolic diseases, strokes, ischemic heart disease, dementia or psychiatric disorders, active liver disease or renal impairment, severe hyperlipidemia, gout, thyroid disease, systemic lupus erythematosus, rheumatoid arthritis, or other chronic inflammatory conditions.
2. Pregnancy
3. Non-adherence to national guidelines for breast cancer screening
4. High risk for breast cancer
5. Any joint surgery within the last 6 months
6. Severe obesity: BMI\>35
7. Migraine with aura
8. Poorly controlled diabetes
9. Use of any form of female hormone supplementation within the past 12 weeks.
10. High venous thromboembolism risk
11. Current cholecystitis, fibroids, or undiagnosed abnormal uterine bleeding.
12. Current smoker.
13. History of endometrial, ovarian, peritoneal, cervical, breast or endocrine-dependent cancers.
14. Receiving treatment for any form of cancer.
15. History of fragility bone fractures within the 2 years.
16. Any other cognitive, musculoskeletal, neurological, and cardiorespiratory condition affecting one's ability to participate in the study.

Where it's running

• National University Hospital
  Singapore, Singapore Recruiting

Study contacts

• Study coordinator: Eu-Leong Yong, PhD
• Email: obgyel@nus.edu.sg
• Phone: 67724278

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Smartphone-guided exercise and monitoring for early postmenopausal women

  This trial will test whether an 8-week, smartphone-delivered multimodal exercise program helps early postmenopausal women improve quality of life, muscle strength, and physical performance.

  Recruiting National Cheng Kung University · Tainan · NCT07131215

• Virtual registry for menopause and perimenopause in Australia

  This study is creating an online registry to collect information from Australian women about their experiences with menopause and perimenopause to help improve healthcare and support for them.

  Recruiting Bespoke Clinical Research · Adelaide · NCT06487130

• Program to help women manage menopausal symptoms

  This study tests a program that helps women manage their menopausal symptoms through exercise and education to improve their overall well-being.

  Recruiting University of Valencia · Valencia and 1 other locations · NCT06419972

• Hop extract vs soy isoflavone for menopausal symptoms

  This study tests whether a full-spectrum hop extract helps reduce menopausal mood symptoms better than soy isoflavones in peri- and postmenopausal women.

  Recruiting Menoclinica by Palacios · Madrid, Madrid · NCT07904390

• Resveratrol and Estrogen Receptors in Postmenopausal Women with CAD

  This study tests whether taking resveratrol is safe and can change estrogen-related markers in postmenopausal women with coronary artery disease.

  Recruiting InCor Heart Institute · São Paulo, São Paulo · NCT07865377

• Ashoka Bark and Shatavari for Menopause

  This 12-week study tests whether a daily Ashoka Bark and Shatavari supplement helps reduce menopausal symptoms in postmenopausal women compared with a placebo.

  Recruiting Vidya USA Corporation · New Port Richey, Florida · NCT07861295

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.