Risk factors for psychosis during the menopause transition
PREMAP - Predictors and Risk Evaluation for Menopause-Associated Psychosis
This project looks for medical, reproductive, psychiatric, and family-history signs that might predict new psychosis in women going through the menopause transition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11238936 on NIH RePORTER |
What this research studies
We will recruit about 179 women who had a first episode of psychosis during the menopause transition and compare them with about 144 women who developed depression during the same time. Researchers will review medical records and collect reproductive, psychiatric, and family-history information to find patterns that preceded the psychosis. Participants will be identified from established local and national sources and may be asked to share records or complete interviews. The aim is to find signals that could help clinicians recognize and respond to risk earlier in the menopause period.
Who could benefit from this research
Good fit: Ideal candidates are women in their 40s–50s who experienced a first episode of psychosis during the menopause transition, and women of similar age who developed depression during the same period for comparison.
Not a fit: People who are male, who are much younger or older than the menopause transition, or who have never experienced mood or psychotic symptoms are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help clinicians identify and monitor women at higher risk of psychosis around menopause so symptoms are caught and treated earlier.
How similar studies have performed: Very little research has directly studied psychosis linked to menopause, so this approach is relatively novel and builds on limited prior evidence.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Powers, Albert R — Yale University
- Study coordinator: Powers, Albert R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.