Patient-ventilator asynchrony in critically ill children
Official title: Patient Ventilator Asynchrony in Critically Ill Children
Funded at Children's Hospital of Los Angeles · NIH-11529197 · Data updated 2026-11-12
A study to understand when ventilators don’t perfectly match a child’s breathing needs and how this affects recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $28,792 |
| NIH project number | 3R01HL164397-04S1 |
| Project ID | NIH-11529197 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents who are mechanically ventilated in the ICU, including those with ARDS characteristics.
✕Less likely to help
Children who are not ventilated or do not have conditions related to PVA likely will not benefit.
What this research studies
This project looks at how often and why the breaths from a ventilator mismatch a child’s own breathing during critical illness. Researchers will review patient data, identify harmful subtypes like double cycled breaths, and explore how these mismatches relate to outcomes such as length of ventilation and complications. The goal is to pinpoint specific problems that could be targeted with adjustments in care to reduce lung stress and diaphragm strain. The work will focus on children with acute respiratory problems and involve analysis of clinical information from the pediatric ICU setting.
Why it matters
Potential benefit: If successful, care teams could tailor ventilator settings to reduce harmful mismatches and potentially shorten ventilation time for severely ill children.
How similar studies have gone: Prior pediatric PVA studies exist but have not clearly linked specific PVA types to outcomes in high-risk patients like those with ARDS.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Khemani, Robinder — Children's Hospital of Los Angeles
- Study coordinator: Khemani, Robinder
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.