Interrupting harmful lung cell interactions to reduce fluid leakage in critically ill children with bronchiolitis
Official title: Interrupting pro-inflammatory pulmonary-vascular cell interactions to reduce pulmonary capillary leak in critically ill children with bronchiolitis
Funded at Yale University · NIH-11401847 · Data updated 2026-11-12
AYA pediatric patients with bronchiolitis who are severely ill may benefit from a study that targets lung cell signals to lessen fluid leak and improve breathing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $879,183 |
| NIH project number | 5R01HL176019-02 |
| Project ID | NIH-11401847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are children under 2 years old with bronchiolitis who are admitted to the hospital and may require respiratory support.
✕Less likely to help
Very mild bronchiolitis cases not requiring hospitalization may not directly benefit from this study.
What this research studies
This study focuses on very young children with bronchiolitis who need intensive care. Researchers will look at how signals from lung cells trigger inflammation and leakiness in the tiny blood vessels, contributing to lung dysfunction. Using human samples and animal models, they aim to map these interactions and identify markers that predict severity. The goal is to find therapies that reduce capillary leak and help children recover better. The work builds on prior data from single-cell analyses of lung tissue and airway samples.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reduce lung fluid buildup and improve outcomes for severely ill infants and young children with bronchiolitis.
How similar studies have gone: Prior studies using IL-1 signaling and alveolar-endothelial interactions have shown promise in animal and human samples, supporting this approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Pierce, Richard W — Yale University
- Study coordinator: Pierce, Richard W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.