Patient-ventilator Asynchrony in Critically Ill Children
Official title: Patient Ventilator Asynchrony in Critically Ill Children
Funded at Children's Hospital of Los Angeles · NIH-11529199 · Data updated 2026-11-12
This grant explores how often and why mechanically ventilated children have mismatches between their own breathing efforts and the ventilator, with the goal of making ventilation safer and more comfortable for kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $28,792 |
| NIH project number | 3R01HL164397-04S2 |
| Project ID | NIH-11529199 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children who are mechanically ventilated in intensive care settings, including those with ARDS.
✕Less likely to help
Children who are not on mechanical ventilation or who do not experience significant PVA may see little direct benefit.
What this research studies
The project focuses on understanding patient-ventilator asynchrony (PVA) in critically ill children, a problem that can lead to longer ventilation and potential complications. Researchers plan to characterize different types of PVA, identify which forms are most harmful, and explore how current ventilator settings contribute to these mismatches. By studying children with and without ARDS, the team aims to pinpoint patterns that could guide more precise ventilator strategies. The ultimate aim is to tailor ventilation to each child’s needs to improve recovery and reduce risks.
Why it matters
Potential benefit: If successful, the work could lead to better, more individualized ventilator settings for children, reducing complications and shortening time on ventilation.
How similar studies have gone: Previous pediatric studies on PVA have been inconclusive, highlighting a need for focused research in higher-risk populations like ARDS.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Khemani, Robinder — Children's Hospital of Los Angeles
- Study coordinator: Khemani, Robinder
Related research
Other NIH-funded projects on the same topics.
-
Personalized oxygen therapy for critically ill adults
A study tests whether customizing oxygen levels for adults on invasive ventilation can lower death rates and complications.
-
Imaging and EHR data combine to predict ICU outcomes with clinician and patient input
Aims to build a computer model that uses chest X-ray images, doctor notes, and electronic health record data to predict outcomes for ICU patients, with input from clinicians, patients’ families, and ethics experts.
-
Teleconsultation to Improve Safety for Critically Ill Infants and Children Before hospital arrival
A national study tests whether remote pediatric expert advice during ambulance transport reduces harm to critically ill babies and kids.
-
Patient-ventilator asynchrony in critically ill children
A study to understand when ventilators don’t perfectly match a child’s breathing needs and how this affects recovery.
-
BrighT STAR SIRIUS: a toolkit to cut unnecessary blood cultures in sick kids
A multi-site study is testing a toolkit to reduce unnecessary blood culture tests in critically ill children to prevent unnecessary treatments and harms.
-
Empowering Parents of Critically Ill Children with a quick, family-focused support program
A short, friendly program helps parents of kids in the PICU feel less stressed and anxious by using a brief, flexible cognitive-behavioral approach.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.