Clinical trial Recruiting at 1 site Interventional Ages 18 to 65

Using parasternal intercostal muscle thickening to help decide when to stop mechanical ventilation

Official title: Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion to Minimize Re-intubation Rate: a Randomized Controlled Trial

Run by Cairo University · NCT07143695 · Data updated 2026-11-12

This trial will test whether adding a bedside ultrasound measurement of parasternal intercostal muscle thickening helps doctors decide when to take critically ill patients off mechanical ventilation to reduce reintubation.

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment200 (estimated)
SponsorCairo University
Academic / other
Locations1 site (Cairo, Giza Governorate)
StatusRecruiting
StartedSeptember 1, 2025
Main results expectedAugust 1, 2026
Study endsAugust 31, 2026
Registry record updatedSeptember 8, 2025
Trial IDNCT07143695 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are critically ill adults mechanically ventilated for at least 24 hours who are undergoing their first spontaneous breathing trial and who can tolerate ultrasound assessment and do not have a tracheostomy.

Probably not a fit

Patients who are tracheostomized, have neuromuscular disorders, have poor ultrasound windows, or who refuse participation are unlikely to benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Critically ill patients who have been mechanically ventilated for 24 hours or more and are undergoing their first spontaneous breathing trial will be enrolled at Cairo University. Participants will receive bedside ultrasound measurement of the parasternal intercostal thickening fraction, with one group having that measurement used as an added weaning criterion and a control group receiving a sham measurement. The study will compare reintubation rates after extubation and track ventilation duration and related complications. The interventional design tests whether the added muscle-based criterion improves decisions about liberation from mechanical ventilation.

Why it matters

Potential benefit: If successful, this approach could reduce unnecessary prolonged ventilation and lower reintubation rates and their complications.

How similar studies have gone: Prior ultrasound studies of respiratory muscles such as diaphragm thickening have shown promise for weaning decisions, but using parasternal intercostal thickening as an additive weaning criterion is relatively novel and not yet definitively proven.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* critically ill patient mechanically ventilated for 24 hours or more first spontaneous breathing trial

Exclusion Criteria:

* patient refusal difficult ultrasound views tracheostomized patient neuromuscular disorders

Where it's running

  • Cairo University
    Cairo, Giza Governorate, Egypt
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.