Using parasternal intercostal muscle thickening to help decide when to stop mechanical ventilation
Official title: Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion to Minimize Re-intubation Rate: a Randomized Controlled Trial
Run by Cairo University · NCT07143695 · Data updated 2026-11-12
This trial will test whether adding a bedside ultrasound measurement of parasternal intercostal muscle thickening helps doctors decide when to take critically ill patients off mechanical ventilation to reduce reintubation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo, Giza Governorate) |
| Status | Recruiting |
| Started | September 1, 2025 |
| Main results expected | August 1, 2026 |
| Study ends | August 31, 2026 |
| Registry record updated | September 8, 2025 |
| Trial ID | NCT07143695 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are critically ill adults mechanically ventilated for at least 24 hours who are undergoing their first spontaneous breathing trial and who can tolerate ultrasound assessment and do not have a tracheostomy.
✕Probably not a fit
Patients who are tracheostomized, have neuromuscular disorders, have poor ultrasound windows, or who refuse participation are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Critically ill patients who have been mechanically ventilated for 24 hours or more and are undergoing their first spontaneous breathing trial will be enrolled at Cairo University. Participants will receive bedside ultrasound measurement of the parasternal intercostal thickening fraction, with one group having that measurement used as an added weaning criterion and a control group receiving a sham measurement. The study will compare reintubation rates after extubation and track ventilation duration and related complications. The interventional design tests whether the added muscle-based criterion improves decisions about liberation from mechanical ventilation.
Why it matters
Potential benefit: If successful, this approach could reduce unnecessary prolonged ventilation and lower reintubation rates and their complications.
How similar studies have gone: Prior ultrasound studies of respiratory muscles such as diaphragm thickening have shown promise for weaning decisions, but using parasternal intercostal thickening as an additive weaning criterion is relatively novel and not yet definitively proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * critically ill patient mechanically ventilated for 24 hours or more first spontaneous breathing trial Exclusion Criteria: * patient refusal difficult ultrasound views tracheostomized patient neuromuscular disorders
Where it's running
-
Cairo University
Cairo, Giza Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Cairo university
- Email: kasralainirec@gmail.com
- Phone: +201275716942
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.