Reestablishing sleep and clock alignment in critically ill patients with a sleep–clock bundle
Official title: Reestablishing Sleep and Circadian Alignment in Medically Critically Ill Patients via a Mechanistic Randomized Controlled Trial of an ICU Sleep Chronobundle (ReAlign-ICU)
Funded at Yale University · NIH-11420590 · Data updated 2026-11-12
A study tests a sleep and circadian rhythm bundle in ICU patients to help restore healthy sleep patterns and bodily rhythms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 21, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $778,389 |
| NIH project number | 5R01HL163659-04 |
| Project ID | NIH-11420590 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in the ICU with acute critical illness who are experiencing sleep and circadian disruption.
✕Less likely to help
Critically ill patients without sleep/circadian disruption or those for whom the intervention is contraindicated may not benefit.
What this research studies
In this trial, critically ill adults in the ICU receive a combined sleep and circadian promotion strategy designed to realign their internal clocks with real-world time. The approach targets multiple sleep domains and circadian signals to improve sleep quality, metabolism, immune function, and overall recovery. Researchers will monitor sleep patterns, circadian markers, and clinical outcomes to see if the bundle leads to better ICU recovery compared with standard care.
Why it matters
Potential benefit: If successful, the bundle could improve sleep, organ function, and recovery for ICU patients.
How similar studies have gone: Previous ICU sleep bundles improved sleep but often did not address circadian alignment, making this approach novel but grounded in prior findings.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Knauert, Melissa P — Yale University
- Study coordinator: Knauert, Melissa P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.