Enoxaparin to prevent catheter-related blood clots in critically ill children by age
Official title: Age-dependent heterogeneity in the efficacy of prophylaxis with enoxaparin against catheter-associated thrombosis in critically ill children
Funded at Yale University · NIH-11163431 · Data updated 2026-11-12
This project looks at whether the blood thinner enoxaparin prevents catheter-related blood clots in critically ill babies and children and whether it works differently for infants under 1 year compared with older kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 10, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $702,712 |
| NIH project number | 5R01HD106326-05 |
| Project ID | NIH-11163431 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are critically ill children in a pediatric intensive care unit who have a central venous catheter and whose medical team is considering preventive anticoagulation.
✕Less likely to help
Children who are not hospitalized, do not have a central line, or who have medical reasons that make anticoagulation unsafe (for example active bleeding or high bleeding risk) would not be expected to benefit.
What this research studies
Many hospitalized children, especially those in intensive care with central venous catheters, are at high risk for catheter-associated deep vein clots, with infants under one year carrying a large share of that risk. The team will compare usual care with giving a preventive dose of enoxaparin to critically ill children with central lines and will look separately at different age groups to see if benefit varies by age. They will use randomized trial data and Bayesian statistical methods to estimate clot risk and treatment effects across ages. Key outcomes include catheter-associated thrombosis and any treatment-related bleeding to weigh safety against benefit.
Why it matters
Potential benefit: If successful, this work could reduce catheter-related blood clots and related complications in critically ill children and lead to age-specific recommendations for safer prevention.
How similar studies have gone: A prior Bayesian phase 2b randomized trial from the team suggested enoxaparin halved catheter clot risk overall, with the apparent benefit mainly in children aged one year and older while infants under one did not clearly benefit.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Faustino, Edward Vincent — Yale University
- Study coordinator: Faustino, Edward Vincent
Related research
Other NIH-funded projects on the same topics.
-
Investigating how age affects the effectiveness of enoxaparin in preventing blood clots in critically ill children
This study is looking at how well enoxaparin, a blood thinner, works for critically ill kids of different ages who are at risk for blood clots, to find the best ways to keep them safe and healthy.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
Personalized oxygen therapy for critically ill adults
A study tests whether customizing oxygen levels for adults on invasive ventilation can lower death rates and complications.
-
Imaging and EHR data combine to predict ICU outcomes with clinician and patient input
Aims to build a computer model that uses chest X-ray images, doctor notes, and electronic health record data to predict outcomes for ICU patients, with input from clinicians, patients’ families, and ethics experts.
-
Teleconsultation to Improve Safety for Critically Ill Infants and Children Before hospital arrival
A national study tests whether remote pediatric expert advice during ambulance transport reduces harm to critically ill babies and kids.
-
Patient-ventilator Asynchrony in Critically Ill Children
This grant explores how often and why mechanically ventilated children have mismatches between their own breathing efforts and the ventilator, with the goal of making ventilation safer and more comfortable for kids.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.