Understanding how ventilators interact with critically ill children
Patient Ventilator Asynchrony in Critically Ill Children
['FUNDING_R01'] · CHILDREN'S HOSPITAL OF LOS ANGELES · NIH-11082244
This study is looking at how well ventilators work for critically ill children who need help breathing, focusing on finding out which breathing mismatches can be most harmful, so we can improve their care and recovery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSPITAL OF LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11082244 on ClinicalTrials.gov |
What this research studies
This research investigates the phenomenon of patient-ventilator asynchrony (PVA) in critically ill children who are mechanically ventilated. It aims to identify the types of PVA that are most harmful and how they affect the patient's health outcomes. By analyzing the mismatch between a child's spontaneous breathing efforts and the ventilator's responses, the study seeks to improve therapeutic strategies for managing ventilation in pediatric patients. The research will involve collecting clinical data and assessing the impact of different PVA subtypes on recovery and complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill children who require mechanical ventilation, particularly those diagnosed with Acute Respiratory Distress Syndrome (ARDS).
Not a fit: Patients who are not mechanically ventilated or those with stable respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved ventilation strategies that enhance recovery and reduce complications for critically ill children.
How similar studies have performed: While PVA has been studied in adults, this research focuses specifically on children, making it a novel approach in pediatric care.
Where this research is happening
LOS ANGELES, UNITED STATES
- CHILDREN'S HOSPITAL OF LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHEMANI, ROBINDER — CHILDREN'S HOSPITAL OF LOS ANGELES
- Study coordinator: KHEMANI, ROBINDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome