Understanding how ventilators interact with critically ill children
Official title: Patient Ventilator Asynchrony in Critically Ill Children
Funded at Children's Hospital of Los Angeles · NIH-11082244 · Data updated 2026-11-12
This study is looking at how well ventilators work for critically ill children who need help breathing, focusing on finding out which breathing mismatches can be most harmful, so we can improve their care and recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $612,963 |
| NIH project number | 5R01HL164397-03 |
| Project ID | NIH-11082244 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill children who require mechanical ventilation, particularly those diagnosed with Acute Respiratory Distress Syndrome (ARDS).
✕Less likely to help
Patients who are not mechanically ventilated or those with stable respiratory conditions may not benefit from this research.
What this research studies
This research investigates the phenomenon of patient-ventilator asynchrony (PVA) in critically ill children who are mechanically ventilated. It aims to identify the types of PVA that are most harmful and how they affect the patient's health outcomes. By analyzing the mismatch between a child's spontaneous breathing efforts and the ventilator's responses, the study seeks to improve therapeutic strategies for managing ventilation in pediatric patients. The research will involve collecting clinical data and assessing the impact of different PVA subtypes on recovery and complications.
Why it matters
Potential benefit: If successful, this research could lead to improved ventilation strategies that enhance recovery and reduce complications for critically ill children.
How similar studies have gone: While PVA has been studied in adults, this research focuses specifically on children, making it a novel approach in pediatric care.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Khemani, Robinder — Children's Hospital of Los Angeles
- Study coordinator: Khemani, Robinder
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.