Testing SGLT2 inhibitors for treating sepsis in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the safety and efficacy of SGLT2 inhibitors in improving clinical outcomes for adults diagnosed with sepsis. The primary objective is to assess how these medications affect patients' recovery and safety, while the secondary objective focuses on their impact on inflammatory markers associated with sepsis. Given the high mortality rates linked to sepsis and the limited effective treatments available, this trial seeks to explore a novel therapeutic option that may address this urgent medical need.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 years or above
* New onset of sepsis within 48 hours defined according to the Sepsis-3 criteria. (≥2 SOFA)
* Provision of signed and dated informed consent form from participant or surrogate
* Ability to take and adhere to oral and enteral medication regimen
* Willingness to comply

Exclusion Criteria:

* Current or recent use of SGLT2 inhibitors (within 12wks prior to randomization)
* Impaired renal function
* Clinically unstable or in refractory hypotension
* History of ketoacidosis
* Gastrointestinal surgery or GI absorption / malabsorption disorder
* Pregnancy
* Known allergic or hypersensitivity reactions to any SGLT2 inhibitors
* Treatment with another investigational drug or other interventions within 30 days prior to trial

Where it's running

• Adult Intensive Care Unit, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong
  Hong Kong, Hong Kong, Hong Kong Recruiting
• The University of Hong Kong
  Hong Kong, Hong Kong Recruiting
• 4/F Main Clinical Block and Trauma Centre, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
  Hong Kong, Hong Kong, Hong Kong Not yet recruiting

Study contacts

• Study coordinator: Pauline Yeung Ng, MBBS, FHKCP
• Email: pyeungng@hku.hk
• Phone: 39103372

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.