Investigating infections in critically ill patients on continuous renal replacement therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on critically ill patients undergoing continuous renal replacement therapy (CRRT) for acute kidney injury (AKI). It aims to analyze the incidence and characteristics of new infections associated with CRRT, as well as the factors influencing these infections. The study is based on findings from a post-hoc analysis of the RICH trial, which suggested a link between filter lifespan and infection rates. By understanding these dynamics, the research seeks to improve patient outcomes in the ICU setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (age ≥18 years)
* Critically ill patients with dialysis-dependent AKI
* Continuous renal replacement therapy (CRRT)
* Written informed consent

Exclusion Criteria:

* Chronic kidney disease with estimated glomerular filtration rate (eGFR)\<30ml/min/1.73m2
* Chronic dialysis dependency
* Kidney transplant
* (Glomerulo-)nephritis, interstitial nephritis, vasculitis
* Patients on immunosuppression
* Patients with chronic inflammatory diseases (e.g. arthritis, HIV, chronic hepatitis)
* Persons with any kind of dependency on the investigator or employed by the sponsor or investigator

Where it's running

• Univ.-Klinik Innsbruck
  Innsbruck, Austria Recruiting
• Universidade de São Paulo
  São Paulo, Brazil Recruiting
• Universitätsklinikum Erlangen-Nürnberg, Abteilung für Nephrologie und Hypertensiologie
  Erlangen, Germany Recruiting
• Kliniken Maria Hilf, Klinik für Anästhesiologie und Operative Intensivmedizin
  Mönchengladbach, Germany Recruiting
• University Hospital Muenster
  Münster, Germany Recruiting

Study contacts

• Principal investigator: Alexander Zarbock, MD — University Hospital Münster
• Study coordinator: Alexander Zarbock, MD
• Email: zarbock@uni-muenster.de
• Phone: +49-251-8347252

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.