Improving drug dosing for critically ill infants with heart disease
Official title: Real-world Data Enables Pharmacokinetic/Pharmacodynamic-based Drug Dosing in Critically Ill Children
Funded at Duke University · NIH-11032773 · Data updated 2026-11-12
This study is looking to find the best way to give heart medicine to critically ill babies, especially those with heart problems, so that it works better and is safer for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 15, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $152,700 |
| NIH project number | 1K23HD116971-01 |
| Project ID | NIH-11032773 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill infants under 11 years old, particularly those diagnosed with heart disease.
✕Less likely to help
Patients who are not critically ill or do not have heart disease may not benefit from this research.
What this research studies
This research focuses on optimizing drug dosing for critically ill infants, particularly those with heart disease, who often experience low cardiac output. The study aims to enhance the effectiveness of inotropes like milrinone by developing a more accurate dosing strategy that considers the changing physiological conditions of these patients. By using real-world data and advanced pharmacokinetic/pharmacodynamic modeling, the research seeks to identify the best dosing regimens that can adapt to the individual needs of each child. This approach aims to reduce therapeutic failures and toxicities associated with current dosing practices.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective drug dosing for critically ill infants, improving their health outcomes.
How similar studies have gone: Previous research has shown promise in using real-world data and advanced modeling techniques to improve drug dosing in pediatric populations, indicating that this approach could be effective.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Thompson, Elizabeth Jaclyn — Duke University
- Study coordinator: Thompson, Elizabeth Jaclyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.