Patient-ventilator mismatch in critically ill children
Official title: Patient Ventilator Asynchrony in Critically Ill Children
Funded at Children's Hospital of Los Angeles · NIH-11324955 · Data updated 2026-11-12
This grant explores how children on ventilators sometimes fight against the machine, and aims to make ventilation more synchronized and safer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $652,815 |
| NIH project number | 5R01HL164397-04 |
| Project ID | NIH-11324955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children who require mechanical ventilation in the ICU, especially those at risk for ARDS.
✕Less likely to help
Children who do not require or will not require mechanical ventilation may not benefit from this research.
What this research studies
The project focuses on patient-ventilator asynchrony (PVA) in mechanically ventilated children, a condition linked to longer ventilation and higher risk of complications. Researchers will examine which types of PVA are most harmful, with special attention to double-cycled breaths that may stress the lungs and diaphragm. The work combines clinical observation with analysis of ventilator patterns to identify meaningful targets for improving care in the PICU setting. Results could guide more precise ventilator settings and interventions tailored to children, including those with ARDS. Families and clinicians may expect findings that help reduce complications and shorten ventilation time for pediatric patients.
Why it matters
Potential benefit: If successful, the research could lead to safer, more effective ventilation for children and fewer days on a ventilator.
How similar studies have gone: Prior studies suggest PVA is common in adults, but pediatric-focused results are limited and this study aims to fill that gap.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Khemani, Robinder — Children's Hospital of Los Angeles
- Study coordinator: Khemani, Robinder
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Patient-ventilator Asynchrony in Critically Ill Children
This grant explores how often and why mechanically ventilated children have mismatches between their own breathing efforts and the ventilator, with the goal of making ventilation safer and more comfortable for kids.
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Patient-ventilator asynchrony in critically ill children
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.