Biorepository to identify immune types in critically ill COVID-19 patients
Official title: BIOREPOSITORY OPTIMIZATION AND USE FOR ENDOTYPING CRITICALLY ILL SARS-COV-2 INFECTED PATIENTS
Funded at New York University School of Medicine · NIH-11159396 · Data updated 2026-11-12
Collecting and analyzing blood and lower-lung samples from critically ill COVID-19 patients to find immune and microbial patterns linked to worse outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 16, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $732,923 |
| NIH project number | 5R33GM147800-04 |
| Project ID | NIH-11159396 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults hospitalized with severe or critical COVID-19 in participating hospitals who can provide consent or have proxy consent and who can provide blood and/or lower-airway samples are ideal candidates.
✕Less likely to help
People with mild COVID-19 treated as outpatients, those without COVID-19, or those unable or unwilling to provide required samples are unlikely to benefit directly from this project.
What this research studies
If I or a loved one is hospitalized with severe COVID-19, this project would collect blood and lower-airway samples over time and store them in a biorepository. Researchers will measure viral levels, the lung and blood microbiome, host gene expression, antibody responses, and metabolites to map how these signals change early and throughout critical illness. The team will compare these molecular patterns to who recovers versus who has prolonged ICU stays or dies to identify distinct patient "endotypes." The goal is to find treatable biological traits that could guide more targeted therapies for critically ill patients.
Why it matters
Potential benefit: Could help identify immune or microbial signatures that point to treatments to reduce mortality and long ICU stays in severe COVID-19.
How similar studies have gone: Prior cross-sectional work from the same group found microbial and host signatures tied to poor outcomes, but the planned longitudinal metabolomic and time-course analyses are a newer extension.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Segal, Leopoldo Nicolas — New York University School of Medicine
- Study coordinator: Segal, Leopoldo Nicolas
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.