Understanding the immune response in critically ill COVID-19 patients
Official title: BIOREPOSITORY OPTIMIZATION AND USE FOR ENDOTYPING CRITICALLY ILL SARS-COV-2 INFECTED PATIENTS
Funded at New York University School of Medicine · NIH-11093654 · Data updated 2026-11-12
This study is looking at patients with severe COVID-19 to find out how their immune systems respond to the virus, which could help create better treatments tailored just for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 16, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $743,678 |
| NIH project number | 4R33GM147800-03 |
| Project ID | NIH-11093654 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients diagnosed with COVID-19 who are receiving intensive care.
✕Less likely to help
Patients with mild COVID-19 symptoms or those not requiring hospitalization may not benefit from this research.
What this research studies
This research focuses on critically ill patients infected with SARS-CoV-2, aiming to identify unique biological traits that could lead to better treatment options. By analyzing samples collected from the lower airways and blood of these patients, the study seeks to understand how individual immune responses affect disease severity and outcomes. The research involves examining microbial environments and immune responses over time to uncover patterns that could inform personalized treatment strategies. Patients' samples will be studied longitudinally to track changes in their immune profiles and viral dynamics.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for critically ill COVID-19 patients.
How similar studies have gone: Previous research has shown promise in understanding immune responses in COVID-19 patients, indicating that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Segal, Leopoldo Nicolas — New York University School of Medicine
- Study coordinator: Segal, Leopoldo Nicolas
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.