Sponsor or institution
Clinical trials and research at University of Missouri-Columbia
As of November 12, 2026, Find a Trial lists 61 clinical trials run by University of Missouri-Columbia that are recruiting, in United States. 1 was first registered in the last 30 days. By phase: Early Phase 1 (6), Phase 4 (6), Phase 2/3 (1), Phase 2 (1). There are also 323 NIH-funded research projects at this institution, with $174.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 61Clinical trials
- 323NIH research projects
- 1New in 30 days
- 1Country
Newest trials
All recruiting trials (61)
-
How egg-based and cell-based flu vaccines compare over time
This study tests whether using egg-based or cell-based flu vaccines, alone or in sequence, changes the immune response to future flu shots in adults.
-
Sirolimus for ApoE4 Carriers: Testing Brain Blood Flow in Women 45-65
Researchers will test whether sirolimus can improve brain blood flow in healthy ApoE4-positive women ages 45 to 65 compared with a placebo.
-
Beta3-adrenergic Receptors and Vascular Function in Aging Women
This trial tests whether activating beta3-adrenergic receptors can improve blood vessel function in aging women undergoing menopause.
-
Talar Osteochondral Lesions in Pilon Fractures: Nano-Arthroscopy During External Fixation
This study tests whether tiny ankle arthroscopy during external fixation can find talar cartilage lesions in adults with pilon fractures and help plan future treatment.
-
How shorter sleep changes blood pressure responses
We will test whether shorter nightly sleep changes blood pressure responses in healthy 18–45-year-olds who are either normal weight or have obesity.
-
Cognitive behavioral therapy for insomnia in people with mild traumatic brain injury
This study will try cognitive behavioral therapy for insomnia (CBT-I) to see if it helps adults with mild traumatic brain injury sleep better and improve daily functioning.
-
See if CBT-I can help with insulin resistance in adults with insomnia
This study tests whether Cognitive Behavioral Therapy for Insomnia (CBT-I) can improve insulin resistance and metabolic measures in adults with insomnia.
-
Project PENGUIN: Profiling phenotypic, epigenetic, and neurogenetic traits in rare neurodevelopmental disorders
This project will try to collect clinical data, genetic and epigenetic samples, imaging, and skin-derived cell models from people with rare neurogenetic disorders like SYT1/BAGOS to help track disease and support future treatments.
-
Carbon‑fiber lateral plate versus plate-and-nail repair for distal femur fractures
This trial will see if a carbon-fiber (CarboFix) lateral femur plate leads to fewer non-unions than the standard plate-plus-nail repair in adults having surgery for a distal femur fracture.
-
Grape powder effects on gut and immune health in adults with obesity
This 12-week test will see if taking 48 g per day of freeze-dried grape powder changes the gut microbiome and immune markers in adults aged 30–45 with obesity.
-
Fibergraft Aeridyan bone graft for open pilon fractures
This observational study will see if using Fibergraft Aeridyan bone graft matrix helps adults with open pilon fractures heal with fewer infections and nonunions.
-
Effects of short-term phenylalanine increases on brain and thinking in adult PKU carriers
This research will test whether taking a dose of phenylalanine raises brain Phe, changes brain activity on MRI, and temporarily affects thinking in adults who carry the PKU gene compared with non-carriers.
-
Remote problem-solving program for autistic teens and their caregiver
This project will test a remote problem‑solving program (PREP) for autistic adolescents and young adults ages 13–21 together with a primary caregiver to help with independence and transition skills.
-
Tracking healing of pars interarticularis injuries with MRI
For teens and young adults with pars interarticularis stress injuries, this project will use repeat MRI scans over 12 months to see if the fractures heal with rest and rehabilitation.
-
7T MRI to detect tiny brain metastases in adults with small-cell lung cancer who decline preventive cranial irradiation.
Try a higher-strength 7T brain MRI to see if it finds tiny brain metastases earlier in adults with small-cell lung cancer who decline preventive cranial radiation.
-
Smart-home sensors and AI to detect dementia-related daily activities
This project will try smart-home sensors and artificial intelligence to detect daily activities linked to mild cognitive impairment or early dementia in adults aged 50 and older who live at home.
-
Validating lab assays, IV catheter techniques, and devices for endocrine, cardiometabolic, and musculoskeletal conditions
This project will test whether laboratory assays, IV catheter methods, and equipment give consistent, reliable results in adults with or without obesity-related, metabolic, or musculoskeletal conditions.
-
Examining how family-based health treatment affects youth executive functioning and weight
This study is testing whether a family-based health program can help overweight teens improve their thinking skills and lose weight over six months.
-
Comparing absorbable and non-absorbable sutures for hip surgery
This study is testing whether absorbable or non-absorbable stitches work better for people having hip surgery to see which one helps them recover more effectively.
-
Evaluating therapy options after thumb joint surgery
This study tests whether going to therapy sessions or doing exercises at home helps people recover better after thumb joint surgery for arthritis.
-
Brain blood flow and lactate responses in people with and without obesity
This project will see if exercise changes brain blood flow and blood lactate in adults with and without obesity.
-
How sympathetic nerve signals affect blood vessels during the menopause transition
This will test whether medicines that block sympathetic nerve signals change blood flow responses in women before, during, and after menopause.
-
Remote fetal monitoring for high-risk pregnancies in Missouri
This study is testing if a new home monitoring system can help pregnant women with high-risk pregnancies feel more satisfied and save money compared to going to the clinic for regular check-ups.
-
Telehealth program to improve self-management after stroke
This study is testing a telehealth program to see if it can help people recovering from a stroke manage their health better and improve their daily lives.
-
Understanding how growth hormone affects insulin-producing cells in people with obesity
This study is trying to see how growth hormone affects insulin-producing cells in obese people aged 18 to 45 who have a family history of type 2 diabetes compared to those who don’t.
-
Understanding how growth hormone affects insulin-producing cells in women with gestational diabetes
This study looks at how growth hormone affects insulin-producing cells in women who had gestational diabetes compared to those who didn't, to see if it helps us understand their risk for type 2 diabetes.
-
Evaluating the role of macrophages in obesity and metabolic function
This study is testing how a specific protein affects fat cells in people with obesity compared to those who are lean, to better understand how obesity impacts health.
-
New psychological tools and anxiety intervention for adolescents with PKU
This study is testing a new online program to help teenagers with PKU manage anxiety and depression better over 10 weeks.
-
Improving cognitive function in breast cancer survivors
This study is testing whether a new training program can help breast cancer survivors improve their thinking skills and daily activities after experiencing memory and attention problems related to their cancer treatment.
-
Understanding blood flow changes in aging women
This study is testing how different treatments affect blood flow in women aged 18 to 55 to better understand changes in their cardiovascular health as they age.
-
Using empagliflozin to reduce arterial stiffness in older adults
This study is testing if a medication called empagliflozin can help older adults aged 60 to 80 reduce stiffness in their arteries over 12 weeks.
-
Investigating how lean beef affects heart health and gut bacteria
This study is testing how eating lean beef compared to plant-based meat affects heart health and gut bacteria in people over six weeks.
-
Examining how aging and menopause affect blood vessel responses to low oxygen levels
This study is testing how aging and menopause affect blood vessel responses to low oxygen levels in women by trying different medications to see how they help.
-
Using a new device to treat aortic aneurysms
This study is testing a new device to see if it can safely treat aortic aneurysms near the kidney arteries in patients who can't have standard surgeries.
-
Monitoring heart and lung health in lung cancer patients receiving radiation and immunotherapy
This study is testing how radiation and immunotherapy for lung cancer affect heart and lung health over time in patients with advanced lung cancer.
-
Natural history assessment of Baker Gordon Syndrome
This study is trying to learn more about how Baker Gordon Syndrome affects people over time by tracking their symptoms and collecting important health information to help with future treatments.
-
Exploring how macrophages affect fat metabolism in obesity
This study tests how a specific protein in immune cells affects fat processing in people with obesity compared to those who are lean.
-
Improving sleep to reduce alcohol use
This study is testing if treating insomnia can help people who drink heavily cut back on their alcohol use.
-
Validation of laboratory measures for metabolism research
This study is testing new lab methods to see if they give reliable results for understanding metabolism in people with obesity and related health issues.
-
Effects of GLP-1 Agonists After Bariatric Surgery
This study is testing whether continuing or stopping a specific diabetes medication after weight loss surgery helps improve health for people who have had gastric bypass or sleeve gastrectomy.
-
Using Propranolol to improve language in people with Primary Progressive Aphasia
This study is testing if the medication Propranolol can help improve language skills and reduce anxiety in people over 50 with Primary Progressive Aphasia.
-
Effects of electrical muscle stimulation exercise on adults with Myasthenia Gravis
This study is testing if whole-body electrical muscle stimulation exercise can help adults with Myasthenia Gravis feel less tired and improve their muscle function.
-
Impact of showering on infection rates and quality of life after breast reconstruction
This study is testing if showering with drain tubes after breast reconstruction surgery affects infection rates and how patients feel during recovery.
-
Prophylactic antibiotics for cat bites on the hand and forearm
This study is testing different lengths of antibiotic treatment for people with cat bites on their hands or forearms to see which works best to prevent infections.
-
Improving skin preparation for foot and ankle surgery
This study tests if a new skin cleaning method before foot and ankle surgery can help lower the risk of infections compared to the usual cleaning method.
-
Effects of high protein diets on atherosclerosis
This study is testing how different high protein diets affect the buildup of plaque in the arteries for people aged 45 to 75 who are overweight or obese.
-
Examining how sex and obesity affect blood vessel responses to low oxygen
This study is testing how being male or female and having obesity affects how blood vessels respond to low oxygen levels, especially in people with sleep apnea, to find better treatments for heart-related issues.
-
Understanding lipoprotein kinetics in type 1 diabetes
This study is testing how type 1 diabetes affects fat and protein levels in the blood to see if it raises the risk of heart problems compared to healthy people.
-
Investigating DPP4's Role in Treating Leukemia
This study is testing if a medication that blocks DPP-4 can help prevent relapse in people with acute myeloid leukemia by looking at their blood and bone marrow.
-
Effects of dietary fiber on gut health and appetite
This study is testing how eating more fiber affects gut health and feelings of fullness in premenopausal men and women aged 20 to 55.
-
Improving sleep in children with autism and insomnia
This study is testing a new sleep therapy for children with autism and insomnia to see if it can help them sleep better and feel more awake during the day.
-
Lowering radiation doses in chemotherapy for HPV-positive throat cancer
This study is testing if giving lower doses of radiation along with regular chemotherapy can help people with HPV-positive throat cancer feel better and have fewer side effects after treatment.
-
Using epidural steroids during surgery for lumbar disc herniation
This study is testing if giving steroids during back surgery for a herniated disc can help reduce inflammation and improve recovery compared to a placebo.
-
Effects of animal and plant proteins on glucose metabolism
This study is testing whether eating more animal or plant proteins can help people improve their blood sugar control and overall metabolic health.
-
Comparing immediate and delayed weight bearing after surgery for diabetic ankle fractures
This study tests whether letting people with diabetic ankle fractures walk right away after surgery, using a special brace, helps them recover better than waiting to bear weight.
-
Registry for 3D talus replacement in patients with avascular necrosis
This study is testing a new 3D talus replacement procedure to see if it helps people with avascular necrosis of the talus recover better and improve their foot function.
-
Low-impact exercise program for joint pain relief
This study is testing if joining low-impact exercise classes can help people with knee, hip, and ankle pain from osteoarthritis feel better and move easier.
-
Treatment for Pilon Fractures with N-Acetylcysteine Injection
This study is testing if an injection of N-acetylcysteine can help people with high energy pilon fractures avoid developing arthritis after their injury.
-
Improving recovery after hand transplantation and nerve injuries using brain stimulation
This study is testing if combining brain stimulation with training can help people recover better after hand transplants or nerve injuries.
-
Detection of tumor cells and DNA in blood, urine, and bone marrow
This study is testing new ways to find cancer cells and DNA in the blood, urine, and bone marrow of people with solid tumors and those at high risk for lung cancer to help improve early detection and personalized treatments.
-
Detection of tumor cells and DNA in blood, urine, and bone marrow of cancer patients
This study is testing if collecting and analyzing tumor cells and DNA from the blood, urine, and bone marrow of cancer patients can help us understand how cancer spreads and comes back, with the hope of creating better treatments.
NIH-funded research (newest 40 of 323)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
-
Boosting immune response to fight cancer
This study is exploring a new way to help your immune system better fight cancer by tweaking certain cells in your body, and it aims to improve treatment for people with advanced cancer.
-
Interface between immune cells and scarring in the eye
This grant looks at how immune cells influence scar formation in the cornea after injury and how this affects vision.
-
Understanding cell-cleanup problems in C9ORF72-related ALS/FTD
Researchers are studying why the body's cell-cleanup systems fail in a genetic form of ALS/FTD to pave the way for better treatments.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
A universal Shigella vaccine using SAVE to protect people of all ages
A new vaccine approach called SAVE aims to prevent Shigella-related dysentery across all ages, including children and adults, by targeting conserved bacterial components.
-
Biomarkers that predict osteoarthritis risk in people at higher risk
A long-term study will look for protein markers in body fluids that could predict who will develop knee osteoarthritis before symptoms appear.
-
Novel CD137 (4-1BB) agonist for cancer prevention
A new CD137/4-1BB activating therapy called SA-4-1BBL is being tested in preclinical models to help prevent cancer development in high-risk people exposed to environmental lung carcinogens.
-
Understanding how T cells influence influenza transmission in a pig model
This project looks at how immune T cells may affect how influenza spreads, using pigs to model human-like transmission and immune responses.
-
Antibody and environmental factors shaping flu spread
A study to understand how antibodies and air conditions influence how easily flu spreads from one person to another, using a pig model to mimic human transmission.
-
Integrative Modeling and Data Analysis Core for Influenza Immunity
A project hub will bring together immune data, aerosol science, and environmental factors to better understand how pre-existing immunity affects airborne influenza transmission.
-
Resource Development Core for Pig Models to Study Airborne Flu Transmission
A research program will develop and provide pig models, including genetically engineered pigs, to study how pre-existing immunity and the environment affect airborne influenza transmission.
-
Administrative Core for a multi-project program
A central management core will coordinate three related research efforts at the University of Missouri, helping scientists work together smoothly and stay within budget and biosafety rules.
-
How our immune system affects how flu spreads through the air
This grant looks at how our antibodies and environmental factors like temperature and humidity influence how airborne flu spreads, with studies in animals and people.
-
Preserving Pediatric Bone Imaging Data for Future Health Research
This grant helps preserve and share key X-ray images and bone-growth data from a long-running pediatric bone health study so researchers and clinicians can learn more about bones from childhood through adulthood.
-
Health changes for family caregivers as they start, go through, and end caregiving in later life
This grant looks at how the health of adults who care for family or friends changes over time as they begin, continue, and finish caregiving.
-
Understanding how dietary fiber shapes gut microbes through multi-omics
A small research project will combine gut bacteria data and other biological information to learn how fiber in the diet changes health-related pathways in people.
-
Corneal gene therapy to treat scarring
Aims to test a gene therapy approach delivered to the cornea to reduce fibrosis and restore clarity in people with corneal scarring.
-
New chemical tools to make peptide drugs that can fight cancer
Researchers are developing two new, safer ways to join amino-acid building blocks into circular peptide drugs that could better reach cancer cells.
-
Helping preschoolers build strong number skills and prevent math learning disability
Trying a family-and-school approach to help preschool children build number skills and lower the risk of long-term math learning disability.
-
Foundational Porcine Stem Cells and Genetic Tools for Large-Animal Models
A project to develop pig stem cells and precise genetic tools to create and study large-animal models that better resemble human biology.
-
Alcohol use patterns around the legal drinking age in young adults
This project follows 20-year-olds as they approach and reach legal drinking age to learn how drinking contexts and consequences change over time.
-
Plan to implement high-quality active surveillance for favorable-risk prostate cancer
A health project to improve how men with favorable-risk prostate cancer are monitored instead of treated right away, helping them avoid unnecessary side effects.
-
Biomarker for gas exchange and blood flow in asthma using special Xenon MRI
A new MRI method using dissolved xenon aims to map lung blood flow and gas exchange in people with asthma.
-
New ways to model RNA structures with computers
A grant to develop new computer methods to better model RNA shapes and behavior, which could help improve RNA-based medicines and vaccines.
-
Tissue transglutaminase as a target to reduce vascular stiffening and high blood pressure in obesity
A study explores whether blocking a specific enzyme in blood vessels can prevent stiffness and high blood pressure that often come with obesity.
-
National Swine Resource and Research Center Renewal Initiative
A grant to keep a pig resource center running so scientists can preserve pig embryos, create genetically engineered pigs, and study pig biology for health research.
-
National Swine Resource and Research Center Core (Years 21-25)
This grant supports a central swine resource center that keeps, quality-controls, and freely shares pig models and biological materials to help researchers study cardiovascular and infectious diseases.
-
National Swine Resource and Research Center (NSRRC) for swine models of human disease
This NIH grant supports a center that provides and maintains genetically engineered pig models and related resources to advance human disease research.
-
Dual filament control of heart power and blood flow
A team at the University of Missouri-Columbia is studying how heart muscle proteins control how hard the heart pumps, with aims to guide new therapies for heart failure.
-
Swine genome editing tools center for human-disease models
A specialized facility will create and store swine models with human-like gene edits to test new gene-editing reagents and study therapies for human diseases.
-
Genome editing testing in animal models to inform future human therapies
A NIH-supported project develops large-animal models and testing protocols to study genome editing therapies that could one day help people with genetic conditions.
-
Coordinating Swine Genome Editing Testing Center
A center at a major university coordinates testing of swine genome editing tools to help researchers create swine models with human genome targets.
-
Swine Somatic Cell Genome Editing Center
A center that helps researchers work with edited pig cells and animals to study genome editing safely and efficiently, with the aim of advancing basic science and future clinical applications.
-
AAV Gene Therapy Vectors: How they enter cells
A gene-delivery tool called AAV is being studied to understand exactly how it gets into human cells, with the goal of making gene therapies safer and more effective.
-
Tumor-Selective Bacterial Therapy to Rebuild the Immune Attack on Pancreatic Cancer
A new bacterial therapy is being tested to target pancreatic cancer, help break down its protective environment, and boost the body’s own immune response.
-
Rocky Mountain Spotted Fever vaccine development for people and dogs
A vaccine is being developed to prevent Rocky Mountain spotted fever, a tick-borne disease that can be severe in people and dogs.
-
Characterization of Shigella’s injection system and how it activates
A study to understand how the Shigella bacteria activates its special needle-like system to infect cells, using advanced imaging to reveal details that could lead to better prevention and treatment for children.
-
Metabolic changes in reactive astrocytes after brain stroke and how they help repair
This project explores how brain support cells called astrocytes change their metabolism after a stroke to help repair the brain.
-
Sleep and insomnia treatment to help heavy drinkers reduce alcohol use
This project tests whether treating insomnia with CBT-I can help adults who drink heavily cut down on alcohol use and improve heart and sleep health.
-
Pavlovian cues and alcohol use: translating brain science to understand risk for problematic drinking
A clinician-relevant study tests how people’s brains assign importance to alcohol cues and whether this linked brain process relates to risky drinking behavior.
Quick answers
How many clinical trials run by University of Missouri-Columbia are recruiting right now?
61, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Early Phase 1: 6, Phase 4: 6, Phase 2/3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.